IMPLANTABLE MEDICAL DEVICE WITH OPTIMIZATION PROCEDURE

• US 20090254139A1
• Filed: 04/13/2006
• Published: 10/08/2009
• Est. Priority Date: 04/13/2006
• Status: Abandoned Application

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Bjorling, Anders
• Application Number:
  US12/296,979
• Publication Number:
  US 20090254139A1
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

In an implantable medical device and a method for the operation thereof, acoustic energy is sensed in a subject in whom the device is implanted, and signals indicative of heart sounds of the heart of the patient are produced over predetermined periods of a cardiac cycle, during successive cardiac cycles. A signal corresponding to the second heart sound (S2) is extracted from the sensed signal, and the respective durations of successive second heart sound signals are determined. An optimization procedure is implemented that includes controlling delivery of pacing pulses based on the determined durations of successive second heart sounds, to determined a combination of stimulation intervals, including at least the AV interval and the VV interval, that causes a substantially synchronized closure of the aortic and pulmonary valves.

Claims

1. An implantable medical device

a pulse generator that emits cardiac stimulating pacing pulses at least one lead comprising electrodes for delivering said pulses to cardiac tissue in at least one ventricle of a heart of a patient;

an acoustic sensor that detects acoustic energy in the patient and that emits a sensed signal corresponding thereto;

a signal processing circuit configured to extract a signal corresponding to a second heart sound (S2) from the sensed signal, said signal being received from said acoustic sensor, and to produce signals indicative of second heart sounds of the heart of said patient over predetermined periods of a cardiac cycle during successive cardiac cycles, and to determine a duration of successive second heart sound signals; and

a controller configured to perform an optimization procedure that controls delivery of said pacing pulses based on the determined durations of successive second heart sound signals to identify a combination of stimulation intervals including at least one of a AV interval and a VV interval that causes a substantially synchronized closure of the aortic and pulmonary valves.

2. The implantable medical device according to claim 1, wherein said controller is configured to control said stimulation intervals such that the durations of said second heart sound signals are within a predetermined range of durations.

3. The implantable medical device according to claim 1, wherein said controller is configured to control said stimulation intervals such that the durations of said heart sound signals are minimized.

4. The implantable medical device according to claim 1, wherein:

said signal processing circuit is configured to also extract a signal corresponding to a first heart sound (S1) from said sensed signal, to produce signals indicative of first heart sounds of the heart of said patient over predetermined periods of a cardiac cycle during successive cardiac cycles, and to determine a duration of successive first heart sound signals; and

said controller is configured to control delivery of said pacing pulses based on determined durations of successive first heart sound signals to identify a VV interval that causes a substantially synchronized closure of the mitral and tricuspid valves.

5. The implantable medical device according to claim 4, wherein said controller is configured to control the VV interval such that the durations of said first heart sound signals are within a predetermined range of durations.

6. The implantable medical device according to claim 4, wherein said controller is configured to control the VV interval such that the durations of said first heart sound signals are minimized.

7. The implantable medical device according to claim 4, wherein said controller is adapted to:

calculate a sum of a duration of a first heart sound and a duration of a second heart sound for successive cardiac cycles; and

control said pacing pulses based on calculated sums of durations to identify a stimulation interval combination that causes a substantially synchronized closure of the mitral and tricuspid valves and/or a substantially synchronized closure of the aortic and pulmonary valves, respectively.

8. The implantable medical device according to claim 7, wherein said controller is configured to:

control said stimulation interval combination such that said sums of a first heart sound and second heart sound are within a predetermined range of duration sums.

9. The implantable medical device according to claim 7, wherein said controller is configured to:

control said stimulation interval combination such that said sums of a first heart sound and second heart sound are minimized.

10. The implantable medical device according to claim 4, with said controller is configured to:

calculate a sum of duration of the first heart sound and the duration of a second heart sound for successive cardiac cycles, with said first heart sound weighted with a first weight and said second heart sound weighted with a second weight.

11. The implantable medical device according to claim 5, wherein said controller is configured to:

calculate the duration of the period of time from start of the first heart sound to the end of the second heart sound for successive heart cycles; and

control said pacing pulses based on said calculated durations of the period of time from start of the first heart sound to the end of the second heart sound to identify a stimulation interval combination that minimizes the systolic phase.

12. The implantable medical device according to claim 11, wherein said controller is configured to:

control said stimulation interval combinations such that the durations of the period of time from start of the first heart sound to the end of the second heart sound are within a predetermined range of durations.

13. The implantable medical device according to claim 12, wherein said controller is configured to:

control said stimulation interval combinations such that the durations of the period of time from start of the first heart sound to the end of the second heart sound are minimized.

14. The implantable medical device according to claim 1, wherein said stimulation interval includes AV and VV intervals and wherein said controller is configured to:

apply selected combinations of AV and VV intervals within at least one predetermined space of possible interval combinations;

evaluate the durations corresponding to the second heart sound resulting from the selected combinations of AV and VV intervals within said predetermined space of possible interval combinations; and

select the combination of AV and VV intervals that results in a minimized duration of the second heart sound as a setting for controlling said pacing pulse.

15. The implantable medical device according to claim 14, wherein the selected combinations are at least the boundary conditions of said combination space and a midpoint combination of said combination space, wherein said controller is configured to:

determine a polynomial using the evaluated durations resulting from the selected combinations that approximates the resulting durations.

16. The implantable medical device according to claim 15, wherein said controller is configured to:

identify a combination of an AV interval and a VV interval that results in a minimum duration of said second heart sound within said combination space using said polynomial.

17. The implantable medical device according to claim 16, wherein said controller is configured to:

select the identified combination of AV and VV intervals as a setting for controlling deliver of said pacing pulses.

18. The implantable medical device according to claim 17, wherein said controller is configured to:

apply the selected combination of AV and VV interval; and

evaluate the duration corresponding to the second heart sound resulting from the identified combination of AV and VV intervals.

19. The implantable medical device according to claim 1 wherein said stimulation interval includes AV intervals and VV intervals, and wherein said controller is configured to:

a) select an initial combination of an AV interval and a VV interval;

b) define a combination space surrounding said initial combination of AV interval and VV interval;

c) apply each combination of AV and VV intervals in said combination space;

d) evaluate the durations corresponding to the second heart sound resulting from the combinations of AV and VV intervals in said first combination space;

e) identify a minimum duration within said first combination space;

f) set the combination of AV and VV interval resulting in said identified minimum pulse as said initial combination;

g) repeat steps a)-e); and

h) perform a comparison step in order to determine whether a minimum duration has been obtained.

20. The implantable medical device according to claim 19, wherein said wherein said controller is configured to:

if the minimum duration identified in the current combination space is shorter than the preceding identified minimum duration, select the combination of AV and VV intervals resulting in the minimum duration of the current combination space as a setting for controlling delivery of said pacing pulses.

21. The implantable medical device according to claim 19, wherein said controller is configured to:

if the minimum duration identified in the current combination space is longer than or substantially equal to the preceding identified minimum duration, repeat steps a)-h).

22. The implantable medical device according to claim 1, wherein said controller is configured to:

calculate each duration as a mean value over a predetermined number of successive durations or during a predetermined period of time.

23. The implantable medical device according to claim 4, wherein said signal processing circuit comprises:

a first bandpass filter that filters off frequency components of the sensed signals from said acoustic sensor outside a first predetermined frequency range for said second heart sounds to extract said signal corresponding to a first heard sound.

24. The implantable medical device according to claim 4, wherein said signal processing circuit comprises a second bandpass filter that filters off frequency components of said sensed signals from said acoustic sensor outside a second predetermined frequency range for said first heart sounds to extract said signal corresponding to a second heart sound.

25. The implantable medical device according to claim 4, wherein said signal processing circuit comprises:

a bandpass filter that filters off frequency components of said sensed signals outside a predetermined frequency range for said first heart sounds and for said second heart sounds.

26. The implantable medical device according to claim 4, wherein said signal processing circuit is configured to calculate the durations based on a part of the sensed signals above a first predetermined amplitude threshold to produce said signals indicative of said first heart sound and a second predetermined amplitude level to produce said signals indicative of said second heart sound.

27. The implantable medical device according to claim 1, further comprising;

a position detector that detects at least one position of said patient; and

said controller is configured to determine whether said patient is in said at least one predetermined specific body position and to initiate said optimization procedure only if said patient is in said predetermined specific body position.

28. The implantable medical device according to claim 1, further comprising:

an activity level sensor that senses an activity level of said patient; and

said controller is configured to determine whether said activity level is within a predetermined activity level range and to initiate said optimization procedure only if said sensed activity level is determined to be within said predetermined activity level range.

29. The implantable medical device according to claim 1, further comprising:

a breathing sensing circuit that senses a breathing cycle of said patient; and

said controller is configured to identify at least one predetermined point in said breathing cycle of said patient and to synchronize sensing sessions of said acoustic sensor with said at least one predetermined point in said breathing cycle of said patient for successive breathing cycles.

30. The implantable medical device according to claim 1, wherein said acoustic sensor is arranged in a lead electrically connectable to said signal processing circuit.

31. The implantable medical device according claim 30, wherein said lead is configured to locate said acoustic sensor at a site selected from the group consisting of in the right ventricle of the heart of said patient, in the left atrium, in a coronary vein, vena cava, on the epicardium, and in the thorax.

32. The implantable medical device according to claim 1 comprising a device housing, and wherein said acoustic sensor is located within the device housing.

33. The implantable medical device according to claim 1, wherein said acoustic sensor is a sensor selected from the group consisting of accelerometers, pressure sensors and microphones.

34. A method for operating an implantable medical device, said device including a pulse generator adapted to produce cardiac stimulating pacing pulses and being connectable to at least one lead comprising electrodes for delivering said pulses to cardiac tissue, comprising the steps of:

sensing an acoustic energy;

producing signals indicative of heart sounds of the heart of said patient over predetermined periods of a cardiac cycle during successive cardiac cycles;

extracting a signal corresponding to a second heart sound (S2) from a sensed signal;

determining durations of successive second heart sound signals; and

performing an optimization procedure, said optimization procedure comprising the step of controlling said pacing pulses based on said determined durations of successive second heart sounds to determine a combination of stimulation intervals including at least one of an AV interval and a VV interval that causes a substantially synchronized closure of the aortic and pulmonary valves.

35. The method according to claim 34, wherein said optimization procedure comprises the step of controlling the stimulation intervals such that the durations of said second heart sound signals are within a predetermined range of durations.

36. The method according to claim 34, wherein said optimization procedure comprises the step of controlling the stimulation intervals such that the durations of said second heart sound signals are minimized.

37. The method according to claim 34, further comprising the steps of:

extracting a signal corresponding to a first heart sound (S1) from a sensed signal;

determining durations of successive first heart sound signals; and

wherein said optimization procedure further comprises the step of controlling said pacing pulses based on determined durations of successive first heart sounds to identify stimulation interval including a VV interval that causes a substantially synchronized closure of the mitral and tricuspid valves.

38. The method according to claim 37, wherein said optimization procedure comprises the step of controlling the VV interval such that the durations of said first heart sound signals are within a predetermined range of durations.

39. The method according to claim 37, wherein said optimization procedure comprises the step of controlling the VV interval such that the durations of said first heart sound signals are minimized.

40. The method according to claim 37, wherein said optimization procedure further comprises the steps of:

calculating a sum of a duration of a first heart sound and a duration of a second heart sound for successive cardiac cycles; and

controlling said pacing pulses based on calculated sums of durations to identify a stimulation interval combination that causes a substantially synchronized closure of the mitral and tricuspid valves and/or a substantially synchronized closure of the aortic and pulmonary valves, respectively.

41. The method according to claim 40, wherein said step of optimizing further comprises the step of

controlling said stimulation interval combination such that said sums of a first heart sound and second heart sound are within a predetermined range of duration sums.

42. The method according to claim 40, wherein said step of optimizing further comprises the step of controlling said stimulation interval combination such that said sums of a first heart sound and second heart sound are minimized.

43. The method according to claim 37, wherein said optimization procedure further comprises the step of:

calculating a sum of a duration of the first heart sound and a duration of the second heart sound for successive cardiac cycles, and weighting said first heart sound with a first weight and weighting said second heart sound with a second weight.

44. The method according to claim 37, wherein said optimization procedure further comprises the steps of:

calculating the duration of the period of time from start of the first heart sound to the end of the second heart sound for successive heart cycles;

and controlling said pacing pulses based on said calculated durations of the period of time from start of the first heart sound to the end of the second heart sound to identify a stimulation interval combination that minimizes the systolic phase.

45. The method according to claim 44, wherein said optimization procedure comprises the steps of:

controlling said stimulation interval combinations such that the durations of the period of time from start of the first heart sound to the end of the second heart sound are within a predetermined range of durations.

46. The method according to claim 44, wherein said optimization procedure comprises the step of:

controlling said stimulation interval combinations such that the durations of the period of time from start of the first heart sound to the end of the second heart sound are minimized.

47. The method according to claim 34, wherein said stimulation intervals includes AV and VV intervals and wherein said optimization procedure comprises the steps of:

applying selected combinations of AV and VV intervals within at least one predetermined space of possible interval combinations;

evaluating the durations corresponding to the second heart sound resulting from the selected combinations of AV and VV intervals within said predetermined space of possible interval combinations; and

selecting the combination of AV and VV intervals that results in a minimized duration of the second heart sound as setting for said device.

48. The method according to claim 47, wherein the selected combinations are the boundary conditions of said combination space and a midpoint combination of said combination space, further comprising the steps of:

determining a polynomial using the evaluated pulse widths resulting from the selected combinations that approximates the resulting durations.

49. The method according to claim 48, further comprising the step of:

identifying a combination of an AV interval and an VV interval that results in a minimum duration of said second heart sound within said combination space using said polynomial.

50. The method according to claim 49, further comprising the step of:

selecting the identified combination of AV and VV intervals as setting for said device.

51. The method according to claim 49, further comprising the step of:

applying the selected combination of AV and VV interval; and

evaluating the duration corresponding to the second heart sound resulting from the identified combination of AV and VV intervals.

52. The method according to claim 34, wherein said optimization comprises the steps of:

a) selecting an initial combination of an AV interval and a VV interval;

b) defining a combination space surrounding said initial combination of AV interval and VV interval;

c) applying each combination of AV and VV intervals in said combination space;

d) evaluating the durations corresponding to the second heart sound resulting from the combinations of AV and VV intervals in said first combination space;

e) identifying a minimum duration within said first combination space;

f) setting the combination of AV and VV interval resulting in said identified minimum pulse as said initial combination;

g) repeating the steps a)-e);

h) performing a comparison step in order to determine whether a minimum duration has been obtained.

53. The method according to claim 52, wherein said comparison step comprises the step of:

if the minimum duration identified in the current combination space is shorter than the preceding identified minimum duration, selecting the combination of AV and VV intervals resulting in the minimum duration of the current combination space as setting for said device.

54. The method according to claim 52, wherein said comparison step comprises the step of:

if the minimum duration identified in the current combination space is longer than or substantially equal to the preceding identified minimum duration, repeating steps a)-h).

55. The method according to claim 34, wherein the step of determining durations comprises the step of calculating each duration as a mean value over a predetermined number of successive durations or during a predetermined period of time.

56. The method according to claim 37, wherein the step of determining durations of successive first heart sound signals, further comprises the step of:

filtering off frequency components of said sensed signals outside a first frequency range for said second heart sounds.

57. The method according to claim 56, wherein the step of determining durations of successive second heart sound signals, further comprises the step of:

filtering off frequency components of said sensed signals outside a second frequency range for said first heart sounds.

58. The method according to claim 37, wherein the step of determining durations of successive first and second heart sound signals, respectively, further comprises the step of:

filtering off frequency components of said sensed signals outside a predetermined frequency range for said first heart sounds and for said second heart sounds.

59. The method according to claim 37, further comprising the step of calculating the durations based on a part of the signals above a first predetermined amplitude threshold for said first heart sound signals and a second predetermined amplitude level for said second heart sound signals.

60. The method according to claim 34, further comprising the steps of:

detecting a body position of said patient;

determining whether said patient is in a predetermined specific body position; and

only if said patient is in said predetermined specific body position, initiating said optimization procedure.

61. The method according to claim 34, further comprising the steps of:

sensing an activity level of said patient;

determining whether said activity level is within a predetermined activity level range; and

only if said sensed activity level is determined to be within said predetermined activity level range, initiating said optimization procedure.

62. The method according to claim 34, further comprising the steps of:

sensing a breathing cycle of said patient;

identifying at least one predetermined point in said breathing cycle of said patient; and

synchronizing sensing sessions of said acoustic sensor with said at least one predetermined point in said breathing cycle of said patient for successive breathing cycles.

63. The method according to claim 34, comprising carrying said acoustic sensor in a lead connectable to said device.

64. The method according claim 63, comprising placing said acoustic sensor carried in said lead at a site selected from the group consisting of the right ventricle of the heart of said patient, in the left atrium, in a coronary vein, vena cava, on the epicardium, and in the thorax.

65. The method according to claim 34, comprising mounting said acoustic sensor within a housing of said device.

66. The method according to claim 34, comprising selecting said acoustic sensor from the group consisting of accelerometers, pressure sensors and microphones.

67-68. -68. (canceled)

69. A computer-readable medium encoded with programming instructions for use in an implantable medical device, said device including a pulse generator that emits cardiac stimulating pacing pulses and at least one lead connected to the pulse generator comprising electrodes for delivering said pulses to cardiac tissue, and an acoustic energy sensor, said programming instructions causing said implantable medical device to:

sense acoustic energy with said acoustic energy sensor;

produce signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles;

extract a signal corresponding to a second heart sound (S2) from the sensed signal from said acoustic energy sensor;

determine durations of successive second heart sound signals; and

perform an optimization procedure including controlling delivery of said pacing pulses dependent on the determined durations of successive second heart sounds to determine a combination of stimulation intervals, including at least one of an AV interval and VV interval, that causes a substantially synchronized closure of the aortic and pulmonary valves.