Programmable Electrode Arrays and Methods for Manipulating and Sensing Cells and Substances Using Same
First Claim
1. A programmable electrode array comprising a plurality of electrodes and at least one programmable memory element physically and/or electrically connected to at least one of the electrodes;
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Abstract
This invention pertains to densely integrated programmable electrode arrays for sensing and manipulating biological cells and substances. Using the programmable electrode arrays according to a method of the invention, it is possible to generate arbitrary, dynamically reconfigurable electric field patterns on and around the electrodes at magnitudes which have been shown to induce neurite outgrowth and enhance cellular regeneration of damaged tissue. It is also possible to use the programmable electrode arrays to sense signals coupled to or in close proximity with the electrodes of the array, and to program arbitrary gain, calibration and offsets onto the individual electrodes of the array and/or their associated circuit elements.
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Citations
20 Claims
- 1. A programmable electrode array comprising a plurality of electrodes and at least one programmable memory element physically and/or electrically connected to at least one of the electrodes;
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19. A programmable electrode array, comprising a plurality of electrodes and at least one programmable amplifier element having one or more inputs and one or more outputs, at least one of the inputs being physically and/or electrically connected to at least one of the electrodes, wherein the programmable amplifier element contains a memory;
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20. A method of manipulating substances or cells comprising the steps of placing the substances or cells onto the surface of or in close proximity to an insulated programmable electrode array, and programming the array to generate a desired pattern of electrical fields across the electrodes of the array, and optionally periodically reprogramming the electrical fields across the electrodes of the array.
Specification