METHODS FOR IDENTIFYING RISK OF BREAST CANCER AND TREATMENTS THEREOF
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Accused Products
Abstract
Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
17 Citations
106 Claims
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1-85. -85. (canceled)
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86. A method for identifying a subject at risk of breast cancer, which comprises detecting the presence or absence of one or more polymorphic variations associated with breast cancer in a nucleotide sequence set forth in SEQ ID NO:
- 1, a substantially identical sequence thereof or complement of the foregoing, in a sample from a subject, whereby the presence of a polymorphic variant associated with breast cancer is indicative of the subject being at risk of breast cancer.
- View Dependent Claims (87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97)
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98. A method of genotyping a nucleic acid which comprises determining the nucleotide corresponding to position 13507 of SEQ ID NO:
- 1 in the nucleic acid.
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99. An isolated nucleic acid which comprises a cytosine at position 13507 of SEQ ID NO:
- 1, or a cytosine at a position corresponding to position 13507 of SEQ ID NO;
1 in a substantially identical nucleic acid. - View Dependent Claims (100, 101, 102)
- 1, or a cytosine at a position corresponding to position 13507 of SEQ ID NO;
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103. A method of targeting information for preventing or treating breast cancer to a subject in need thereof, which comprises detecting the presence or absence of one or more polymorphic variations associated with breast cancer in SEQ ID NO:
- 1, a substantially identical nucleotide sequence thereof or complement of the foregoing in a nucleic acid sample from a subject, and
directing information for preventing or treating breast cancer to a subject in need thereof based upon the presence or absence of the one or more polymorphic variations in the nucleic acid sample. - View Dependent Claims (104, 105, 106)
- 1, a substantially identical nucleotide sequence thereof or complement of the foregoing in a nucleic acid sample from a subject, and
Specification