Cell cycle regulation and differentiation
First Claim
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1. A method of regulating proliferation or differentiation of a neural cell comprising contacting said neural cell with a bioactive agent effective in modulating the activity or expression level of transcription factor ZFP536 or KLF9, thereby regulating said proliferation or differentiation of said neural cell.
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Abstract
The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.
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Citations
34 Claims
- 1. A method of regulating proliferation or differentiation of a neural cell comprising contacting said neural cell with a bioactive agent effective in modulating the activity or expression level of transcription factor ZFP536 or KLF9, thereby regulating said proliferation or differentiation of said neural cell.
- 2. A method of regulating proliferation or differentiation of a neural cell comprising contacting said neural cell with a bioactive agent effective in modulating the activity or expression level of p57Kip2 in said neural cell, thereby regulating said proliferation or differentiation of said neural cell.
- 3. A method of regulating proliferation or differentiation of a neural cell comprising contacting said neural cell with a bioactive agent effective in modulating the activity or expression level of one or more oligodendrocyte-regulated transcription factors or myelin-enriched genes implicated in a discrete phase of differentiation of said neural cell.
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4. (canceled)
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7-12. -12. (canceled)
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18-24. -24. (canceled)
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