COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS
First Claim
1. A method for treating a condition in a mammalian subject in need thereof, comprising administering an effective amount of a treatment composition comprising at least one component selected from the group consisting of:
- bumetanide and ethacrinic acid, wherein the condition is selected from the group consisting of;
seizures;
seizure disorders;
epilepsy; and
status.
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Accused Products
Abstract
The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neuropsychiatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and/or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed.
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Citations
15 Claims
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1. A method for treating a condition in a mammalian subject in need thereof, comprising administering an effective amount of a treatment composition comprising at least one component selected from the group consisting of:
- bumetanide and ethacrinic acid, wherein the condition is selected from the group consisting of;
seizures;
seizure disorders;
epilepsy; and
status. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- bumetanide and ethacrinic acid, wherein the condition is selected from the group consisting of;
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9. A method for treating a condition in a mammalian subject in need thereof, comprising administering an effective amount of a treatment composition comprising at least one component selected from the group consisting of:
- thiazide and thiazide-like compositions, wherein the condition is selected from the group consisting of;
seizures;
seizure disorders;
epilepsy; and
status. - View Dependent Claims (10, 11, 12, 13, 14, 15)
- thiazide and thiazide-like compositions, wherein the condition is selected from the group consisting of;
Specification