Intragastric Volume-Occupying Device

• US 20090259246A1
• Filed: 04/14/2008
• Published: 10/15/2009
• Est. Priority Date: 04/14/2008
• Status: Abandoned Application

• Current Assignee: W. L. Gore & Associates (W.L. Gore & Associates)
• Original Assignee: W. L. Gore & Associates (W.L. Gore & Associates)
• Inventors: Ristic-Lehmann, Cedomila, Everson, David C., Sherman, Melissa, Bucher, Richard A., Eskaros, Sherif
• Application Number:
  US12/102,389
• Publication Number:
  US 20090259246A1
• Time in Patent Office: Days
• US Class Current: 606/192
• CPC Class Codes: A61F 5/003 inflatable
• CPC Class Codes: A61F 5/0036 Intragastrical devices

Abstract

An intragastric device having a non-degradable porous membrane enclosing a material which expands upon contact with fluid, and causes the volume of the device to increase is described. The intragastric device is useful for managing satiety and weight loss.

Claims

1. An intragastric device comprising a non-degradable porous membrane enclosing a material which expands upon contact with fluid, and causes the volume of the device to increase.

2. The intragastric device of claim 1 wherein the non-degradable porous membrane is water permeable.

3. An intragastric device of claim 1 wherein said device is sized to be delivered orally.

4. An intragastric device of claim 2 wherein said device is sized to be delivered orally via a swallowable capsule.

5. The intragastric device of claim 1 further comprising at least one controlled deactivation means.

6. An intragastric device of claim 1 wherein the non-degradable porous membrane maintains a constant relative pore size during expansion of the material.

9. An inflatable gastric device of claim 6 wherein said fibrillated membrane is not disruptable under physiological conditions for a period of at least ten days.

10. The inflatable gastric device of claim 6 further comprising a rupture valve.

7. An inflatable gastric device comprising a non-degradable fibrillated membrane enclosing an expandable material wherein the expandable material causes the device to expand upon contact with gastric liquids.

8. An inflatable gastric device of claim 7 wherein said inflatable gastric device is sized to be delivered orally.

11. An intragastric device comprising:

a. a non-degradable porous membrane, and

b. a swellable material enclosed within the porous membrane to form an initial shape wherein said initial shape expands to an expanded volume upon contact with liquids to form a final shape.

12. The intragastric device of claim 11 wherein the final shape has at least 5 times volume of initial shape.

13. The intragastric device of claim 11 wherein the final shape has about 2-3000 times volume of initial shape.

14. The intragastric device of claim 11 wherein the initial shape has volume between 0.1 ml to 28 ml.

15. The intragastric device of claim 11 wherein the initial shape has volume between 0.5 ml to 10 ml.

16. The intragastric device of claim 11 wherein the final shape has volume between 20 ml to 1500 ml.

17. The intragastric device of claim 11 wherein the final shape has volume between 100 ml to 500 ml.

18. The intragastric device of claim 11 wherein said initial shape is selected from kidney, oblong, cylindrical, oval, rectangular, ellipse, triangle, conical, trapezoidal, star-like, pear-like, umbrella-like, butterfly, bow-tie, snare-like, coil, helical, spiral, doughnut, or spherical shape configuration.

19. The intragastric device of claim 11 wherein the final shape is selected from kidney, oblong, cylindrical, oval, rectangular, ellipse, triangle, conical, trapezoidal, star-like, pear-like, umbrella-like, butterfly, bow-tie, snare-like, coil, helical, spiral, doughnut, or spherical shape configuration.

20. The intragastric device of claim 11 wherein said final shape has a different configuration than said initial shape.

21. The intragastric device of claim 11 further comprising a contrast agent.

22. The intragastric device of claim 11 wherein a portion of the device is radiopaque.

23. An intragastric device comprising:

a. at least one non-degradable porous membrane,

b. a swellable material enclosed within the at least one porous membrane to form multiple units, and

c. non-degradable outer shell membrane which contains the multiple units.