OSMOTIC REACTION DETECTOR FOR MONITORING BIOLOGICAL AND NON-BIOLOGICAL REACTIONS
First Claim
1. An osmotic reaction detector for monitoring reactivity in reactions between a first material of interest and a second material of interest by measuring pressure changes in said detector as a result of a change in concentration of impermeable species in said detector, said detector comprising:
- a body defining an interior chamber;
a semi-permeable membrane incorporated within said body, wherein said semi-permeable membrane is impermeable to said first and second materials of interest and reaction products formed therefrom and permeable to a carrier fluid; and
a pressure sensor for measuring charges in osmotic pressure of the detector.
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Accused Products
Abstract
An apparatus and system for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes of reaction detector. The reaction detector is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10−7 M.
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Citations
20 Claims
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1. An osmotic reaction detector for monitoring reactivity in reactions between a first material of interest and a second material of interest by measuring pressure changes in said detector as a result of a change in concentration of impermeable species in said detector, said detector comprising:
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a body defining an interior chamber; a semi-permeable membrane incorporated within said body, wherein said semi-permeable membrane is impermeable to said first and second materials of interest and reaction products formed therefrom and permeable to a carrier fluid; and a pressure sensor for measuring charges in osmotic pressure of the detector. - View Dependent Claims (2, 3, 4, 5, 6, 14, 15)
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7. An osmotic reaction detector for monitoring reactivity in reactions between a first material of interest and a second material of interest by measuring pressure changes in said detector as a result of a change in concentration of impermeable species in said detector, said detector comprising:
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a body defining an interior chamber; a semi-permeable membrane incorporated within said body, wherein said semi-permeable membrane is impermeable to said first and second materials of interest and reaction products formed therefrom and permeable to a carrier fluid, said semi-permeable membrane positioned in fluid contact with and between a reaction mixture and a reference solution, said reaction mixture comprising a carrier fluid, the first material of interest and the second material of interest and said reference solution comprising any one or combination of the first material, the second material, a surrogate reference material and the carrier fluid; and a pressure sensor positioned and designed to detect and measure changes in pressure in the reference solution which occur as a result of a change in concentration in said reaction mixture of one or more of said first material, second material, surrogate reference material or reaction products formed from said first and second materials. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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16. An osmotic reaction detector system, including a plurality of osmotic reaction detectors for monitoring reactivity in reactions between a first material of interest and a second material of interest by measuring pressure changes in said detectors as a result of a change in concentration of impermeable species in said detectors, said detectors of the system comprising:
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a body defining an interior chamber; a semi-permeable membrane incorporated within said body, wherein said semi-permeable membrane is impermeable to said first and second materials of interest and reaction products formed therefrom and permeable to a carrier fluid, said semi-permeable membrane positioned in fluid contact with and between a reaction mixture and a reference solution, said reaction mixture comprising a carrier fluid, the first material of interest and the second material of interest and said reference solution comprising nay one or combination of the first material, the second material, a surrogate reference material and a carrier fluid; and a pressure sensor positioned and designed to detect and measure changes in pressure in the reference solution which occur as a result of a change in concentration in said reaction mixture of one or more of said first material, second material, surrogate reference material or reaction products formed from said first and second materials. - View Dependent Claims (17, 18, 19, 20)
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Specification