COSMETIC SKIN LIGHTENING FORMULATION

• US 20090263513A1
• Filed: 04/18/2008
• Published: 10/22/2009
• Est. Priority Date: 04/18/2008
• Status: Abandoned Application

• Current Assignee: Jan Marini Skin Research Incorporated
• Original Assignee: Jan Marini Skin Research Incorporated
• Inventors: Marini, Jan
• Application Number:
  US12/106,054
• Publication Number:
  US 20090263513A1
• Time in Patent Office: Days
• US Class Current: 424/729
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin

Abstract

The present invention features novel cosmetic skin care compositions for lightening hyperpigmentation.

Claims

1. A skin lightening cosmetic composition for topical application comprising:

from about 0.1 to about 10% by weight a stable kojic acid derivative;

from about 0.1 to about 5% by weight retinoid;

from about 0.1 to about 5% by weight of a resorcinol derivative; and

a cosmetically acceptable vehicle.

2. The skin lightening composition of claim 1, wherein the stable kojic acid derivative has the structure:

where R₁ and R₂ are independently selected from C1-C22 alkyls, having not more than 1, unsaturated bonds.

3. The skin lightening composition of claim 2, wherein the stable kojic acid derivative is kojic dipalmitate at a concentration of from about 2.5% to about 5%.

4. The skin lightening composition of claim 1, wherein the retinoid is retinol.

5. The skin lightening composition of claim 4, wherein retinol is present at a concentration of about 1.5% to about 2.5%.

6. The skin lightening composition of claim 1, wherein the resorcinol derivative has the structure:

where R₁ is a C1 to C12 alkyl.

7. The skin lightening composition of claim 6, wherein the resorcinol derivative is 4.-hexylresorcinol at a concentration of from about 0.75% to about 2%.

8. The skin lightening composition of claim 1, wherein the stable kojic acid derivative is kojic dipalmitate at a concentration of 2.5% to 5%, the retinoid is retinol at a concentration of.5% to 2.5%;

and the resorcinol derivative is 4-hexylresorcinol at a concentration of 0.75% to 2%.

9. The skin lightening composition of claim 8, further comprising salicylic acid at a concentration of 0.5% to 2%.

10. The skin lightening composition of claim 9, further comprising a permeation enhancer at a concentration of 2.5% to 7.5%.

11. The skin lightening composition of claim 10, wherein the permeation enhancer is diethylene glycol monoethyl ether.

12. The cosmetic composition of claim 8, further comprising from about 0.1 to about 5% by weight of one or more of azelaic acid, salicylic acid, lactic acid and glycolic acid.

13. The cosmetic composition of claim 8, further comprising from about 0.1 to about 5% by weight of one or more of 0.01 to 1% licorice extract and green tea extract.

14. A method of lightening a hyperpigmented condition of the skin, comprising:

topically applying a cosmetic composition comprising;

from about 0.1 to about 10% by weight a stable kojic acid derivative;

from about 0.1 to about 5% by weight retinoid;

from about 0.1 to about 5% by weight of a resorcinol derivative; and

a cosmetically acceptable vehicle.

15. The method of claim 14, wherein the stable kojic acid derivative is kojic dipalmitate at a concentration of 2.5% to 5%, the retinoid is retinol at a concentration of.5% to 2.5%;

and the resorcinol derivative is 4-hexylresorcinol at a concentration of 0.75% to 2%.

16. The method of claim 15, wherein the cosmetic composition further comprises salicylic acid at a concentration of 0.5% to 2%.

17. The method of claim 15, wherein the cosmetic composition further comprises a permeation enhancer at a concentration of 2.5% to 7.5%.

18. The method of claim 15, wherein the cosmetic composition further comprises from about 0.1 to about 5% by weight of one or more of azelaic acid, salicylic acid, lactic acid and glycolic acid.

19. The method of claim 15, wherein the cosmetic composition further comprises from about 0.1 to about 5% by weight of one or more of 0.01 to 1% licorice extract and green tea extract.

20. The method of claim 15, wherein the skin condition is selected from the group consisting of solar lentigenes, melasma, chloasma, scars, freckles, and other local hyperpigmented regions of the skin.