SYSTEM AND METHOD FOR NON-INVASIVELY MONITORING CONDITIONS OF A OBJECT

• US 20090264722A1
• Filed: 06/01/2009
• Published: 10/22/2009
• Est. Priority Date: 06/04/2007
• Status: Active Grant

• Current Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Original Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Inventors: Rokni, Michal, Metzger, Yaacov, Pery-Shechter, Revital
• Granted Patent: US 8,143,605 B2
• Time in Patent Office: Days
• US Class Current: 600/324
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method and system are presented for use in determining one or more parameters of a subject. A region of interest of the subject is irradiated with acoustic tagging radiation, which comprises at least one acoustic tagging beam. At least a portion of the region of interest is irradiated with at least one electromagnetic beam of a predetermined frequency range. Electromagnetic radiation response of the at least portion of the region of interest is detected and measured data indicative thereof is generated. The detected response comprises electromagnetic radiation tagged by the acoustic radiation. This enables processing of the measured data indicative of the detected electromagnetic radiation response to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and outputting data indicative of the at least one determined parameter.

Claims

1. A system for use in determining one or more parameters of a subject, the system comprising:

an acoustic unit configured and operable for irradiating a region of interest with acoustic tagging radiation comprising at least one acoustic tagging beam;

an optical unit configured and operable for irradiating at least a portion of the region of interest with at least one electromagnetic beam of a predetermined frequency range, detecting an electromagnetic radiation response of said at least portion of the region of interest and generating data indicative thereof, said response comprising electromagnetic radiation tagged by the acoustic radiation, said data being indicative of the at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation; and

a control unit comprising;

a processing and analyzing utility configured and operable for analyzing said data indicative of the electromagnetic radiation response and generating output data indicative of at least a blood flow parameter; and

a data presentation utility responsive to the output data of the processing and analyzing utility for presenting said at least blood flow parameter.

2. The system according to claim 1, wherein said data processing and analyzing utility is configured and operable for analyzing said data indicative of the electromagnetic radiation response and generating output data indicative of at least one of oxygen saturation and hemoglobin concentration parameters.

3. The system according to claim 2, wherein said control unit is configured and operable concurrently display the blood flow parameter and said at least one of oxygen saturation and hemoglobin concentration parameters.

4. The system according to claim 1, wherein the acoustic unit has one of the following configurations:

(1) comprises a single acoustic port for locating it at a certain distance from the region of interest;

(2) comprises a plurality of spaced apart acoustic ports at different locations with respect to the region of interest;

(3) has an essentially annular shape;

(4) has at least one aperture.

5. The system according to claim 1, wherein the optical unit has at least one of the following configurations:

(i) comprises a plurality of light output ports at different locations with respect to the region of interest;

(ii) comprises a plurality of light input ports at different locations with respect to the region of interest;

(iii) comprises at least one light input port and at least light output port accommodated within an annular aperture of the acoustic unit;

(iv) comprises at least one light input port located within at least one aperture of the acoustic unit, and a plurality of light output ports arranged in an essentially circular array around said at least one light input port outside the acoustic unit.

6. The system according to claim 1, wherein the acoustic unit comprises a signal generator and an acoustic transducer arrangement, said signal generator being configured and operable to generate at least one coded acoustic wave in the form of a predetermined function of at least one parameter of the acoustic radiation varying over time during a predetermined time interval used for measurements, said at least one coded continuous acoustic wave forming said at least one acoustic tagging beam.

7. The system according to claim 6, wherein said coded acoustic wave is a continuous wave in the form of the predetermined function having narrow autocorrelation.

8. The system according to claim 7, wherein the signal generator is configured and operable to generate at least one coding signal in the form of an arbitrary sequence to actuate the acoustic transducer arrangement to thereby modulate output of the acoustic transducer arrangement in at least one of frequency, phase and amplitude parametric domains.

9. The system according to claim 1, wherein said control unit is configured and operable to operate the acoustic and optical units and for receiving and analyzing said data indicative of the electromagnetic radiation response to identify the tagged electromagnetic radiation and corresponding locations in the subject.

10. The system according to claim 6, wherein the control unit is configured for processing said data indicative of the detected electromagnetic radiation response by cross-correlating said data with said coded signal.

11. The system according to claim 10, wherein the control unit is configured for performing said cross-correlation at different time delays from a start of the acoustic wave generation.

12. The system according to claim 11, wherein the control unit is configured for determining the cross correlation at each delay as intensity of the tagged electromagnetic radiation corresponding to a distance from the acoustic transducer equal to a product of a speed of acoustic signal propagation in the subject'"'"'s medium and the delay time.

13. A method for use in determining one or more parameters of a subject, said method comprising:

(a) irradiating a region of interest of the subject with acoustic tagging radiation, and irradiating at least a portion of the region of interest with at least one electromagnetic beam of a predetermined frequency range;

(b) detecting an electromagnetic radiation response of said at least portion of the region of interest comprising electromagnetic radiation tagged by the acoustic radiation, and generating data indicative of the detected electromagnetic radiation response;

(c) processing and analyzing said data indicative of the detected electromagnetic radiation response, determining at least a blood flow parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and presenting output data comprising at least blood flow parameter.

14. The method according to claim 13, wherein said output data comprises at least one of oxygen saturation and hemoglobin concentration parameters.

15. The method according to claim 14, comprising concurrently displaying the blood flow parameter and at least one of the oxygen saturation and hemoglobin concentration parameters.

16. The method according to claim 13, wherein the acoustic tagging radiation comprises at least one acoustic tagging beam being a coded continuous acoustic wave.

17. The method according to claim 16, wherein said coded continuous acoustic wave is in the form of a predetermined function of at least one parameter of the acoustic radiation varying over time during a measurement time interval, the acoustic wave being coded by modulating said at least one wave parameter selected from the following:

phase, amplitude, frequency, frequency gradient, phase jump, duty cycle, chirp gradient.

18. The method according to claim 17, wherein said predetermined time function has a narrow autocorrelation.

19. The method according to claim 18, comprising generating the phase modulated continuous acoustic wave as a sequence of pulses having equal or not values of at least one of the following parameters:

duration, amplitude, frequency, frequency gradient, phase jump, duty cycle and chirp gradient.

20. The method according to claim 18, wherein said acoustic tagging beam is produced by operating an acoustic transducer with at least one coding signal in the form of an arbitrary sequence to thereby modulate output of the acoustic transducer in at least one of frequency, phase and amplitude parametric domains.

21. The method according to claim 18, comprising processing said data indicative of the detected electromagnetic response by cross-correlating said data with either said coded signal or a function of said coded signal.

22. The method according to claim 21, wherein the cross correlation is performed at different time delays from a start of the acoustic wave generation.

23. The method according to claim 18, comprising processing the data indicative of the detected response, said processing comprising:

correlating said data against an arbitrary sequence, used for modulating output of an acoustic transducer, or against a function of the arbitrary sequence, at different time delays from a start of the acoustic wave generation, and processing the correlated signal to search for a phase shift that gives best correlation for each delay.

24. The method according to claim 21, wherein said processing comprises correlating the data indicative of the detected response with a complex phasor representation of the acoustic sequence and taking an absolute value of the resulting phasor.

25. The method according to claim 18, comprising irradiating the region of interest with a plurality of the coded continuous acoustic waves and comprising at least one of the following:

producing the coding signals in the form of arbitrary sequences corresponding to the coded continuous acoustic waves, respectively, having a near zero cross correlation at any time delay longer than a predetermined time delay; and

directing the plurality of said continuous acoustic waves towards the region of interest so as to constructively and/or destructively interfere in at least a part thereof thereby controlling the acoustic radiation power in a volume defined by said at least part of the region of interest.

26. The method according to claim 22, wherein the cross correlation at each delay corresponds to intensity of the tagged light in the detected response corresponding to a distance from the acoustic transducer equal to a product of a speed of acoustic signal propagation in the subject'"'"'s medium and the delay time, said cross correlation being used for determining optical properties of the region of interest at different distances from the acoustic transducer, thereby determining said blood flow and one of the oxygen saturation and hemoglobin content parameters.

27. The method according to claim 22, wherein an amplitude of the cross correlation at each delay CCA(τ

,λ

) is determined as a product of light distribution for wavelength λ

at the corresponding distance z and an amplitude of the acoustic wave (PA(τ

)) at said distance.

28. The method according to claim 22, wherein the blood flow is determined by monitoring at least one of the peak amplitude and noise level of the cross correlation signal for at least one wavelength of light, as a function of time, thereby determining changes in the flow rate, thereby enabling determination of the flow distribution by monitoring said changes as a function of depth.

29. The method according to claim 22, wherein the oxygen saturation is determined by calculating the spatial gradient of the logarithm of the ratio of two light distributions obtained by detecting the light illuminating the tissue at two different illuminating wavelengths;

repeating said calculation by detecting the light illuminating the tissue at two different wavelengths, at least one wavelength being different from said two illuminating wavelengths; and

determining the oxygen saturation by mapping the two calculations to known theoretical or empirical calculations of blood oxygen saturation levels.