Pacemaker for treating physiological system dysfunction
First Claim
1. A method for treating a dynamical disorder, comprising:
- acquiring a plurality of signals corresponding to a plurality of electrodes, wherein the plurality of electrodes corresponds to a plurality of brain sites;
computing a correlation between a number of signals within the plurality of signals, the number of signals corresponding to a number of brain sites within the plurality of brain sites;
computing a feedback signal that is a function of the correlation and the number of signals; and
applying the feedback signal to a number of transmit electrodes within the plurality of electrodes, the number of transmit electrodes corresponding to the number of brain sites.
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Accused Products
Abstract
Disclosed is a device and method for preventing seizures due to physiological system dysfunction. The method is based on a conjectural model of the brain wherein each brain site is modeled as a chaotic oscillator; a normal brain generates an internal feedback signal to prevent long-term entrainment among the oscillators; and a pathological brain fails to provide this feedback signal. The device of the present invention measures and characterizes the brain sites to determine if entrainment is occurring among the oscillators, derives an appropriate feedback signal to counteract the entrainment, and applies the feedback signal to the critical brain sites. The feedback signal generated by the device supplements or takes the place of the feedback signal that would otherwise be generated by the normal brain.
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Citations
28 Claims
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1. A method for treating a dynamical disorder, comprising:
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acquiring a plurality of signals corresponding to a plurality of electrodes, wherein the plurality of electrodes corresponds to a plurality of brain sites; computing a correlation between a number of signals within the plurality of signals, the number of signals corresponding to a number of brain sites within the plurality of brain sites; computing a feedback signal that is a function of the correlation and the number of signals; and applying the feedback signal to a number of transmit electrodes within the plurality of electrodes, the number of transmit electrodes corresponding to the number of brain sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A device for treating a dynamical disorder, comprising:
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a plurality of electrodes corresponding to a plurality of brain sites; and a microprocessor having a computer readable medium encoded with a program for acquiring a plurality of signals corresponding to the plurality of electrodes;
computing a correlation between a number of signals within the plurality of signals, the number of signals corresponding to a number of brain sites within the plurality of brain sites;
computing a feedback signal that is a function of the correlation and the number of signals; and
applying the feedback signal to a number of transmit electrodes within the plurality of electrodes, the number of transmit electrodes corresponding to the number of brain sites. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method for treating a dynamical disorder, comprising:
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acquiring a plurality of signals corresponding to a plurality of electrodes, the plurality of electrodes corresponding to a plurality of brain sites identifying entrainment between a number of brain sites within the plurality of brain sites; and performing neurocontrol on the number of brain sites, based on a result of identifying entrainment. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification