AUTOMATED ASSESSMENT OF OPTIC NERVE HEAD WITH SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

• US 20090268159A1
• Filed: 04/21/2009
• Published: 10/29/2009
• Est. Priority Date: 04/23/2008
• Status: Active Grant

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Inventors: Ishikawa, Hiroshi, Wollstein, Chaim-Gadi, Xu, Juan, Schuman, Joel Steven
• Granted Patent: US 7,992,999 B2
• Time in Patent Office: Days
• US Class Current: 351/206
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/1233 for measuring blood flow, e.g. at the retina
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: G06T 2207/10016 Video; Image sequence
• CPC Class Codes: G06T 2207/10072 Tomographic images
• CPC Class Codes: G06T 2207/20081 Training; Learning
• CPC Class Codes: G06T 2207/30041 Eye; Retina; Ophthalmic
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/12 Edge-based segmentation
• CPC Class Codes: G06T 7/42 using transform domain methods

Abstract

A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and monitoring of progression.

Claims

1. A method of assessing status of a portion of a retina, which portion contains the optic disc, wherein said optic disc comprises the disc cupping, said method comprising the steps of:

(A) obtaining at least one enface image generated from a plurality of three-dimensional optical coherence tomographic images of said portion;

(B) generating a weighted edge map to delineate the margin of the optic disc in said enface image;

(C) in each image of said plurality, identifying spatial coordinates for the internal limiting membrane and the retinal pigment epithelium layer in the optic disc;

then

(D) generating at least one three-dimensional surface image of the optic disc from said enface image, wherein depth in said image corresponds to said spatial coordinates of the internal limiting membrane;

(E) obtaining at least one of (i) reference points, (ii) a reference line, and (iii) a reference plane with respect to at least one of (1) the retinal pigment epithelium layer and (2) said margin of the optic disc from each image of said plurality or said three-dimensional surface image;

then

(F) using said reference line or reference plane to delineate the margin of the disc cupping in said surface image;

then

(G) determining shape information of said portion from said three-dimensional surface image; and

, from said shape information,

(H) generating at least one three-dimensional point distribution model to classify said portion with respect to predetermined values reflecting retinal status.

2. The method as recited in claim 1, wherein step (E) further comprises fitting a first segment and a second segment of said layer in each image of said plurality with two straight lines, respectively, which lines intersect the margin of the optic disc, to obtain (i) a first reference point and second reference point at the intersection, respectively, and (ii) at least one of a reference line and a reference plane that, relative to the retina, is anterior to the first and second reference points, wherein the first and second segments of the layer are opposite each other on the optic disc in each image of said plurality.

3. A program that makes an information processing apparatus execute a method as recited in claim 1.

4. A computer-readable recording medium, comprising the program as recited in claim 3 recorded thereon.

5. The program as recited in claim 3, wherein the information process apparatus is a part of an imaging instrument.