THIOLATED CHITOSAN GEL

• US 20090269417A1
• Filed: 04/23/2009
• Published: 10/29/2009
• Est. Priority Date: 04/24/2008
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Tijsma, Edze Jan, Schaffhausen, Nancy, Gonzalez, Maria Nieves
• Application Number:
  US12/429,135
• Publication Number:
  US 20090269417A1
• Time in Patent Office: Days
• US Class Current: 424/616
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/0046 Ear
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/04 for throat disorders
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

Bodily tissue and structures may be coated with a protective gel layer made from a two-part composition whose first part contains thiolated chitosan and whose second part contains sufficient oxidizing agent or external crosslinking agent so that when the two parts are mixed and coated onto the tissue or structure the mixture will form a protective gel layer in less than 30 minutes.

Claims

1. A method for treating a mucosal tissue in the ear, nose or throat during or immediately after surgery, which method comprises:

a) applying a fluid layer containing a mixture of thiolated chitosan and an oxidizing agent or external crosslinking agent to a mucosal tissue in the ear, nose or throat during or immediately after surgery, and

b) allowing the mixture to form a protective gel layer in situ as a tissue sealant.

2. A method according to claim 1 comprising applying the fluid layer to a nasal cavity.

3. A method according to claim 1 comprising applying the fluid layer to a sinus cavity.

4. A method according to claim 1 comprising applying the fluid layer to a middle or inner ear.

5. A method according to claim 1 comprising applying the fluid layer by spraying, lavage, misting, mopping, wicking or dripping.

6. A method according to claim 1 wherein the fluid layer contains hydrogen peroxide.

7. A method according to claim 1 wherein the fluid layer contains genipin.

8. A method according to claim 1 wherein gelation occurs in less than 30 minutes.

9. A method according to claim 1 wherein gelation occurs in less than 10 minutes.

10. A two-part composition for protecting a mucosal tissue in the ear, nose or throat, the first part comprising thiolated chitosan and the second part comprising sufficient oxidizing agent or external crosslinking agent so that when the two parts are mixed and coated onto the mucosal tissue the mixture will form a protective gel layer in less than 30 minutes.

11. A composition according to claim 10 wherein the first and second parts are each packaged in a barrel of a multiple-barrel syringe.

12. A composition according to claim 10 wherein the first part is a free-flowing dry powder.

13. A composition according to claim 10 wherein the first and second part are each an aqueous solution.

14. A composition according to claim 10 wherein the second part contains hydrogen peroxide.

15. A composition according to claim 10 wherein the second part contains genipin.

16. A composition according to claim 10 wherein when the two parts are mixed a gel layer will form in less than 10 minutes.

17. A composition according to claim 10 wherein when the two parts are mixed a gel layer will form in less than 5 minutes.

18. A fluid layer atop a mucosal tissue in the ear, nose or throat, the layer comprising thiolated chitosan and sufficient oxidizing agent or external crosslinking agent so that a protective gel layer will form in situ in less than 30 minutes.

19. A fluid layer according to claim 18 containing hydrogen peroxide.

20. A fluid layer according to claim 18 containing genipin.

21. A fluid layer according to claim 18 containing about 1 to about 20 wt. % thiolated chitosan and about 0.01 to about 1 wt. % oxidizing agent.

22. A fluid layer according to claim 18 containing about 1 to about 20 wt. % thiolated chitosan and about 0.1 to about 10 wt. % external crosslinking agent.