PROGNOSTIC MARKERS FOR CLASSIFYING COLORECTAL CARCINOMA ON THE BASIS OF EXPRESSION PROFILES OF BIOLOGICAL SAMPLES
First Claim
Patent Images
1. A method for predicting the probability of recurrence of a colorectal carcinoma or of metastases in remote organs of a patient with colon cancer, comprising determining a gene expression profile of 30 marker genes (as depicted in SEQ ID NOs:
- 1 to
30) or of a selection thereof.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to the use of gene expression profiles for predicting the probability of recurrence or metastases to develop in remote organs of patients from which a primary colon carcinoma has been removed.
-
Citations
29 Claims
-
1. A method for predicting the probability of recurrence of a colorectal carcinoma or of metastases in remote organs of a patient with colon cancer, comprising determining a gene expression profile of 30 marker genes (as depicted in SEQ ID NOs:
- 1 to
30) or of a selection thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 16, 17, 18, 19, 27)
- 1 to
-
9. (canceled)
-
10. (canceled)
-
11. (canceled)
-
12. (canceled)
-
13. (canceled)
-
14. (canceled)
-
15. (canceled)
- 20. A prognostic portfolio consisting of the genes with the nucleic acid sequences of SEQ ID NO 1 to SEQ ID NO 30, their reverse complementary sequences or parts of these sequences or combinations thereof, which are suitable for detecting the differential expression of the sequences contained in the portfolio.
-
25. (canceled)
-
28. (canceled)
-
29. A kit for determining the status of a colorectal carcinoma, the kit comprising materials that permit the detection of nucleic acids comprising SEQ ID NOs 1-30 in a sample from said colorectal carcinoma.
Specification