METHODS OF DETECTING AND TREATING MYOCARDIAL ISCHEMIA AND MYOCARDIAL INFARCTION

• US 20090269796A1
• Filed: 11/25/2008
• Published: 10/29/2009
• Est. Priority Date: 12/05/2007
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Fifer, Michael A., Gerszten, Robert, Sabatine, Marc S.
• Application Number:
  US12/277,740
• Publication Number:
  US 20090269796A1
• Time in Patent Office: Days
• US Class Current: 435/29
• CPC Class Codes: G01N 2800/324 Coronary artery diseases, e.g. angina pectoris, myocardial infarction
• CPC Class Codes: G01N 33/6893 related to diseases not provided for elsewhere

Abstract

Methods of detecting and treating myocardial ischemia and myocardial infarction based on the differential expression of metabolic products are described herein.

Claims

1. A method of detecting myocardial ischemia or myocardial infarction in a subject comprising detecting in a biological sample obtained from the subject a change in the amount of at least one member selected from the group consisting of malonic acid, asymmetric dimethyl arginine (ADMA), succinic acid, anthanilic acid, acetyl-CoA, asymmetric dimethyl arginine (ADMA)/symmetric dimethyl arginine (SDMA), and a metabolic product thereof, thereby detecting myocardial ischemia or early myocardial infarction in the subject.

9. The method of claim 1, wherein the change comprises an increase in the amount of at least one member of the group consisting of malonic acid, succinic acid, anthanilic acid, acetyl-CoA, asymmetric dimethyl arginine (ADMA)/symmetric dimethyl arginine (SDMA), and a metabolic product thereof.

16. The method of claim 1, wherein myocardial infarction is detected.

17. The method of claim 16, wherein the myocardial infarction is early myocardial infarction.

18. The method of claims 1, wherein myocardial ischemia is detected.

19. The method of claims 1, wherein the biological sample comprises a blood sample or a preparation thereof.

22. The method of claims 1, wherein the change is detected after administration of a controlled ischemic insult or planned myocardial infarction to the subject.

23. The method of claim 22, wherein the controlled ischemic insult comprises exercise testing, and the planned myocardial infarction comprises alcohol septal ablation for hypertrophic cardiomyopathy.

2-8. -8. (canceled)

10-15. -15. (canceled)

20. (canceled)

21. (canceled)

24-95. -95. (canceled)

96. A method of detecting myocardial ischemia or myocardial infarction in a subject comprising detecting a decrease in the amount of at least one member of the group consisting of cholic acid, tyrosine, sucrose, trimethylamine-N-oxide, homoserine, threonine, choline, proline, 3-phosphoglyceric acid, and a metabolic product thereof in a biological sample obtained from the subject, thereby detecting myocardial ischemia or early myocardial infarction in the subject.

99. The method of claim 96, wherein myocardial infarction is detected.

101. The method of claim 96, wherein myocardial ischemia is detected.

102. The method of claim 96, wherein the biological sample comprises a blood sample or a preparation thereof.

105. The method of claim 96, wherein the decrease or increase is detected after administration of a controlled ischemic insult or planned myocardial infarction to the subject.

106. The method of claim 105, wherein the controlled ischemic insult comprises exercise testing, and the planned myocardial infarction comprises alcohol septal ablation for hypertrophic cardiomyopathy.

97. A method of detecting myocardial ischemia or myocardial infarction in a subject comprising detecting an increase in the amount of at least one member of the group consisting of Ile/Leu, taurine, aminoisobutyric acid, glyceraldehyde, xanthine, adenosine diphosphate (ADP), acetoacetate, carnitine, lactose, mevalonic acid lactone, 1-methylhistamine, glutamine, glutamic acid, orotic acid, glycerol-3-P, glycerate-2-P, adenosine monophosphate (AMP), malic acid, ascorbic acid, deoxycytidine monophosphate (DCMP), deoxycytidine diphosphate (DCDP), metanephrine, dimethyl glycine, creatine, ribose-5-P/ribulose-5-P, and a metabolic product thereof in a biological sample obtained from the subject, thereby detecting myocardial ischemia or early myocardial infarction in the subject.

120. The method of claim 97, wherein myocardial infarction is detected.

121. The method of claim 97, wherein myocardial ischemia is detected.

122. The method of claim 97, wherein the biological sample comprises a blood sample or a preparation thereof.

123. The method of claim 97, wherein the decrease or increase is detected after administration of a controlled ischemic insult or planned myocardial infarction to the subject.

124. The method of claim 123, wherein the controlled ischemic insult comprises exercise testing, and the planned myocardial infarction comprises alcohol septal ablation for hypertrophic cardiomyopathy.

98. (canceled)

100. (canceled)

103. (canceled)

104. (canceled)

107-119. -119. (canceled)