PROTECTIVE GEL BASED ON CHITOSAN AND OXIDIZED POLYSACCHARIDE

• US 20090270346A1
• Filed: 04/23/2009
• Published: 10/29/2009
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gonzales, Maria Nieves, Tijsma, Edze Jan, TenBroek, Erica M., Schaffhausen, Nancy
• Granted Patent: US 9,433,636 B2
• Time in Patent Office: Days
• US Class Current: 514/55
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/718 Starch or degraded starch, e.g. amylose, amylopectin
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 26/009 Materials resorbable by the body
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

Bodily tissue and structures may be protected using a fluid layer containing a mixture of chitosan and oxidized polysaccharide. The mixture forms a protective gel layer via in situ crosslinking. Compared to crosslinking using a low molecular weight aldehyde such as glutaraldehyde or genipin, oxidized polysaccharides appear to provide faster gelation while avoiding the use of potentially less bioacceptable low molecular weight aldehydes.

Claims

1. A fluid layer atop a bodily tissue or structure, the layer comprising chitosan and oxidized polysaccharide in amounts sufficient to form a protective gel layer in situ.

2. A fluid layer according to claim 1 wherein the tissue comprises nasal tissue.

3. A fluid layer according to claim 1 wherein the tissue comprises cartilage or bone.

4. A fluid layer according to claim 1 wherein the chitosan is an unmodified chitosan or a chitosan salt.

5. A fluid layer according to claim 1 wherein the chitosan is a chitosan derivative.

6. A fluid layer according to claim 1 wherein the oxidized polysaccharide comprises starch.

7. A fluid layer according to claim 1 wherein the oxidized polysaccharide comprises cellulose.

8. A fluid layer according to claim 1 wherein the oxidized polysaccharide comprises chitin, chitosan, chondroitin sulfate, dextran, glycogen or hyaluronic acid.

9. A fluid layer according to claim 1 wherein the chitosan and oxidized polysaccharide are combined in a ratio of about 10:

1 to about 1;

20.

10. A fluid layer according to claim 1 wherein the chitosan and oxidized polysaccharide are combined in a ratio of about 3:

1 to about 1;

5.

11. A fluid layer according to claim 1 further comprising phosphate ions.

12. A method for treating bodily tissue or structure, which method comprises:

a) applying to such tissue a fluid layer containing a mixture of chitosan and an oxidized polysaccharide, and

b) allowing the mixture to form a protective gel layer in situ.

13. A method according to claim 12 comprising applying the fluid layer to a nasal or sinus cavity.

14. A method according to claim 12 comprising applying the fluid layer to a middle or inner ear.

15. A method according to claim 12 comprising applying the fluid layer to an opening, recess, passageway or joint in a limb.

16. A method according to claim 12 comprising applying the fluid layer to an opening, recess, passageway or joint in a spinal column.

17. A method according to claim 12 comprising applying the fluid layer from a multiple-barrel syringe.

18. A method according to claim 12 comprising applying the fluid layer by spraying.

19. A method according to claim 12 wherein the chitosan is an unmodified chitosan or a chitosan salt.

20. A method according to claim 12 wherein the chitosan is a chitosan derivative.

21. A method according to claim 12 wherein the oxidized polysaccharide comprises starch.

22. A method according to claim 12 wherein the oxidized polysaccharide comprises cellulose.

23. A method according to claim 12 wherein the oxidized polysaccharide comprises chitin, chitosan chondroitin sulfate, dextran, glycogen or hyaluronic acid.

24. A method according to claim 12 wherein the chitosan and oxidized polysaccharide are combined in a ratio of about 10:

1 to about 1;

20.

25. A method according to claim 12 wherein the chitosan and oxidized polysaccharide are combined in a ratio of about 3:

1 to about 1;

5.