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SPIRO ANTIBIOTIC DERIVATIVES

  • US 20090270375A1
  • Filed: 08/29/2007
  • Published: 10/29/2009
  • Est. Priority Date: 08/30/2006
  • Status: Active Grant
First Claim
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1. A compound of formula (I) wherein R1 represents H, alkyl, alkoxy, cyano or halogen;

  • one of U and X represents CH or N and the other represents CH, or, in the case of U, may also represent CRa and, in the case of X, may also represent CRb;

    Ra represents halogen;

    Rb represents halogen or alkoxy;

    B represents N, D represents CH2 and A represents CH(OH)CH2 or CH2CH2, or B represents CH, D represents CH2 or O and A represents OCH2, CH2CH(OH), CH(OH)CH2, CH(OH)CH(OH), CH═

    CH, CH2CH2 or NHCO, or also B represents C(OH), D represents CH2 and A represents OCH2, CH2CH(OH), CH(OH)CH2, CH(OH)CH(OH), CH═

    CH, CH2CH2 or NHCO;

    R2 represents H, alkyl, alkenyl, hydroxyalkyl or alkoxycarbonylalkyl; and

    E represents naphthyl or a binuclear heterocyclic group;

    or a salt of the compound.

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