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COMBINATIONS OF CLASS-I SPECIFIC HISTONE DEACETYLASE INHIBITORS WITH PROTEASOME INHIBITORS

  • US 20090270419A1
  • Filed: 09/11/2007
  • Published: 10/29/2009
  • Est. Priority Date: 09/15/2006
  • Status: Abandoned Application
First Claim
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1. A combination of a proteasome inhibitor and a histone deacetylase inhibitor of formula (I) the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof, wherein is a radical selected from R5 is selected from hydrogen;

  • thienyl;

    thienyl substituted with di(C1-6alkyl)aminoC1-6alkyl, or C1-16alkylpiperazinylC1-6alkyl;

    furanyl;

    phenyl;

    phenyl substituted with one substituents independently selected from di(C1-4alkyl)aminoC1-4alkyloxy, di(C1-4alkyl)amino, di(C1-4alkyl)aminoC1-4alkyl, di(C1-4alkyl)aminoC1-4alkyl(C1-4alkyl)aminoC1-4alkyl, pyrrolidinylC1-4alkyl, pyrrolidinylC1-4alkyloxy or C1-14alkylpiperazinylC1-4alkyl.

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