NON-INVASIVE GLUCOSE SENSOR

• US 20090270700A1
• Filed: 04/18/2007
• Published: 10/29/2009
• Est. Priority Date: 04/21/2006
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: von Basum, Golo, Van Herpen, Maarten Marinus, Such, Olaf
• Application Number:
  US12/297,235
• Publication Number:
  US 20090270700A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

Apparatus and method for sensing HO activity, and in particular blood glucose level based on an analyte level determination, the analyte being carboxyhemoglobin. In a preferred embodiment, HO activity and/or blood glucose level are extrapolated from Hb-CO level by determining an intermediate CO level. The apparatus and method are preferably non invasive.

Claims

1. Apparatus for determining a blood glucose level, the apparatus comprising:

blood generated CO determination means for determining a blood generated CO level, and

first extrapolating means (80) for extrapolating said blood glucose level according to said blood generated CO level.

2. Apparatus according to claim 1, said blood generated CO determination means comprising:

breath CO sensing means (50) for sensing an exhaled CO level in breath,

Hb-CO sensing means (10) for sensing a blood carboxyhemoglobin (Hb-CO) level, and

blood generated CO level extrapolating means (60) for extrapolating said blood generated CO level according to said Hb-CO level and said exhaled CO level.

3. Apparatus according to claim 2, said blood generated CO level extrapolating means (60) further comprising CO computing means (62) for computing a computed CO level from said blood Hb-CO level.

4. Apparatus according to claim 2, said breath CO sensing means (62) being adapted to measure both inhaled CO level and exhaled CO level.

5. Apparatus according to claim 4, said blood generated CO level being a function of said exhaled CO level, said inhaled CO level, and said computed CO level.

11. Apparatus according to claim 2, said Hb-CO sensing means comprising:

illuminating means for illuminating a part of the body with a plurality of wavelengths,

collecting means for collecting transmitted and/or reflected light, and

Hb-CO computing means for computing the Hb-Co level responsive to transmitted, emitted and/or reflected light intensity.

12. Apparatus according to claim 11, said Hb-CO sensing means for sensing said Hb-CO level further comprising:

illuminating means for illuminating a part of the body with a plurality of wavelengths,

collecting means for collecting transmitted and/or reflected light,

spectroscopic means for separating transmitted and/or reflected light depending on spectral bands from said plurality of wavelengths, and

Hb-CO computing means for computing said Hb-CO level according to separated transmitted/reflected light intensity.

13. Apparatus according to claim 11, said plurality of wavelengths being in the range of about 450 nm to about 950 nm.

14. Apparatus according to claim 1, further comprising calibration means for calibrating said blood glucose level and/or said HO activity obtained by extrapolation, said calibration means comprises reference glucose sensing means for sensing a reference glucose level, and comparison means for comparing values of said blood glucose level obtained at different measurement times

15. Apparatus according to claim 14, said comparison means being adapted to make at least one of the following comparisons:

ratios of said blood generated CO to said exhaled CO, ratios of said blood generated CO to said computed CO, said ratios being obtained at different measurement times.

6. Apparatus for determining a blood glucose level, the apparatus comprising:

Hb-CO sensing means (10) for sensing a blood carboxyhemoglobin (Hb-CO) level, and

second extrapolating means (20) for extrapolating said blood glucose level based on said Hb-CO level.

7. Apparatus according to claim 6, said second extrapolating means comprising:

CO level computing means for computing a carbon monoxide (CO) level according to said Hb-CO level.

8. Apparatus according to claim 7, said second extrapolating means further comprising glucose level computing means for computing said blood glucose level according to said computed CO level.

9. Apparatus according to claim 8, further comprising CO level calibration means for including an ambient CO level in the computation of said glucose level according to said computed CO level.

10. Apparatus according to claim 9, said CO level calibration means comprising

CO sensing means for sensing a ambient CO level, and

modelling means for modelling Hb-CO level responsive to said ambient CO level.

16. Method for non invasively determining a blood glucose level, comprising the steps of:

determining a blood generated CO level, and

extrapolating said glucose level according to said Hb-CO level.

17. Method according to claim 16, the step of extrapolating said glucose level comprising the steps of:

sensing a breath CO level in breath,

sensing a blood carboxyhemoglobin (Hb-CO) level, and

extrapolating said HO activity and/or said blood generated CO according to said Hb-CO level and said breath CO level.

18. Method for non invasively determining a blood glucose level, comprising the steps of:

sensing a blood carboxyhemoglobin (Hb-CO) level, and

extrapolating said glucose level according to said Hb-CO level.

19. Method according to claim 18, the step of extrapolating said glucose level comprising the steps of:

computing a carbon monoxide (CO) level according to said Hb-CO level, and

computing said glucose level according to said computed CO level.