REAL-TIME DETECTION OF VASCULAR CONDITIONS OF A SUBJECT USING ARTERIAL PRESSURE WAVEFORM ANALYSIS
First Claim
1. A method of detecting a vascular condition in a subject comprising:
- receiving a signal corresponding to an arterial blood pressure;
calculating a cardiovascular parameter using the arterial blood pressure signal based on a set of factors including one or more parameters effected by the vascular condition; and
monitoring the cardiovascular parameter to determine if there is a statistically significant change over time,wherein detection of the statistically significant change in the cardiovascular parameter indicates the vascular condition.
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Abstract
Methods for the detection of vascular conditions such as vasodilation in a subject are described. The methods involve receiving a signal corresponding to an arterial blood pressure and calculating one or more cardiovascular parameters from the arterial blood pressure. The cardiovascular parameters are calculated using factors impacted by vascular conditions such as vasodilation. Factors impacted by these vascular conditions include the area under the systolic portion of the arterial blood pressure signal, the duration of systole, and the ratio of the duration of the systole to the duration of the diastole. By monitoring cardiovascular parameters that are calculated using factors impacted by vascular conditions such as vasodilation for changes indicating the vascular conditions, such vascular conditions can be detected.
88 Citations
86 Claims
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1. A method of detecting a vascular condition in a subject comprising:
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receiving a signal corresponding to an arterial blood pressure; calculating a cardiovascular parameter using the arterial blood pressure signal based on a set of factors including one or more parameters effected by the vascular condition; and monitoring the cardiovascular parameter to determine if there is a statistically significant change over time, wherein detection of the statistically significant change in the cardiovascular parameter indicates the vascular condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of detecting a vascular condition in a subject comprising:
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receiving a signal corresponding to an arterial blood pressure; calculating a first cardiovascular parameter using the arterial blood pressure signal based on a first set of factors including one or more of (a) a parameter based on the shape of the beat-to-beat arterial blood pressure signal and at least one statistical moment of the arterial blood pressure signal having an order of one or greater, (b) a parameter based on a heart rate of the subject, and (c) a set of anthropomorphic parameters of the subject; calculating a second cardiovascular parameter using the arterial blood pressure signal based on the first set of factors and one or more parameters effected by the vascular condition; and calculating a difference factor by subtracting the first cardiovascular parameter from the second cardiovascular parameter, wherein the difference factor being greater than a predetermined threshold value indicates the vascular condition. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method of detecting a vascular condition in a subject comprising:
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receiving a signal corresponding to an arterial blood pressure; calculating a first cardiovascular parameter using the arterial blood pressure signal based on a first set of factors including one or more of (a) a parameter based on the shape of the arterial blood pressure signal and at least one statistical moment of the arterial blood pressure signal having an order of one or greater, (b) a parameter based on a heart rate of the subject, and (c) a set of anthropomorphic parameters of the subject; and calculating a second cardiovascular parameter using the arterial blood pressure signal based on the first set of factors and one or more parameters effected by the vascular condition; wherein a ratio of the second cardiovascular parameter to the first cardiovascular parameter greater than a predetermined value indicates the vascular condition. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86)
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Specification