Prediction of Rapid Symptomatic Blood Pressure Decrease

• US 20090272678A1
• Filed: 06/04/2007
• Published: 11/05/2009
• Est. Priority Date: 06/07/2006
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Solem, Kristian, Olde, Bo, Sornmo, Leif
• Granted Patent: US 8,287,725 B2
• Time in Patent Office: Days
• US Class Current: 210/90
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence

Abstract

The invention relates to prediction of a rapid symptomatic drop in a subject'"'"'s blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfils a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.

Claims

1. An alarm arrangement for predicting rapid symptomatic blood pressure decrease in a subject, the arrangement comprising:

a pulse recording device configured to repeatedly register a pulse shape parameter in a peripheral body part of the subject, said pulse recording device having a pulse oximetry instrument configured to register the pulse shape parameter based on light response variations in at least one blood vessel of the subject; and

a control unit configured to receive the pulse shape parameter and investigate whether the pulse shape parameter fulfills an alarm criterion, wherein if said alarm criterion is fulfilled, said control unit causes an alarm to be activated, said control unit having a processing unit configured to;

calculate an initial pulse magnitude measure based on a pulse shape parameter received at a first instance;

store the initial pulse magnitude measure in a memory means associated with the control unit;

calculate, during a measurement period subsequent to the first instance, a respective pulse magnitude measure based on each of a number of received pulse shape parameters; and

investigate, for each pulse magnitude measure in the measurement period, whether the pulse magnitude measure fulfills a decision criterion relative to the initial pulse magnitude measure, and wherein said decision criterion is fulfilled, said processing unit is further configured to generate an alarm triggering signal.

2. The arrangement according to claim 1, wherein the processing unit is configured to regard the decision criterion as fulfilled if:

an examined pulse magnitude measure of a given pulse shape parameter is below a threshold value calculated based on the initial pulse magnitude measure; and

a predetermined amount of the pulse magnitude measures of the pulse shape parameters, received within a test period after the registering of the given pulse shape parameter, are below the threshold value.

3. The arrangement according to claim 2, wherein the predetermined amount is a value representing approximately 50% to approximately 100% of the pulse magnitude measures of the pulse shape parameters received within the test period.

4. The arrangement according to claim 2, wherein the predetermined amount represents all the pulse magnitude measures of the pulse shape parameters received within the test period.

5. The arrangement according to claim 2, wherein the test period is an interval selected from a range extending from approximately three minutes to approximately fifteen minutes.

6. The arrangement according to claim 5, wherein the test period is approximately five minutes long.

7. The arrangement according to claim 2, wherein the processing unit is configured to calculate the threshold value by:

normalizing the initial pulse magnitude measure; and

dividing the normalized initial pulse magnitude measure by a predefined denominator.

8. The arrangement according to claim 7, wherein the processing unit is configured to, during the measurement period, calculate a pulse magnitude measure for a received pulse shape parameter by dividing an original measure with the initial pulse magnitude measure.

9. The arrangement according to claim 8, wherein the predefined denominator is a value selected from a range extending from approximately 1 to approximately 5.

10. The arrangement according to claim 1, wherein the arrangement comprises:

an auxiliary recording means configured to repeatedly register a bio-impedance parameter representing a degree of contraction of the subject'"'"'s capillary blood vessels, and

the processing unit is further configured to receive the bio-impedance parameter, investigate whether the bio-impedance parameter fulfills an auxiliary alarm criterion, and generate the alarm triggering signal if the auxiliary alarm criterion is fulfilled.

11. The arrangement according to claim 1, wherein the arrangement is configured to predict rapid symptomatic blood pressure decrease in a subject undergoing blood treatment, and the processing unit is configured to calculate the initial pulse magnitude measure based on a pulse shape parameter received during an initial phase of the blood treatment.

12. A medical system configured to perform blood treatment of a subject, wherein the system comprises:

a dialysis machine configured to perform extracorporeal blood treatment of the subject; and

the alarm arrangement according to claim 1.

13. A method of predicting rapid symptomatic blood pressure decrease in a subject, the method comprising:

registering a pulse shape parameter in respect of a peripheral body part of the subject at repeated occasions,

investigating, for each pulse shape parameter, whether the pulse shape parameter fulfills an alarm criterion, and if the alarm criterion is fulfilled;

causing an alarm to be activated, wherein the registering of the pulse shape parameter involves a pulse oximetry measurement, said pulse shape parameter being determined based on light response variations in at least one blood vessel of the subject, and the method further comprising;

calculating an initial pulse magnitude measure based on a pulse shape parameter received at a first instance;

storing the initial pulse magnitude measure in a memory means;

calculating, during a measurement period subsequent to the first instance, a respective pulse magnitude measure based on each of a number of received pulse shape parameters;

investigating, for each pulse magnitude measure in the measurement period, whether the measure fulfills a decision criterion relative to the initial pulse magnitude measure, and if the decision criterion is fulfilled;

generating an alarm triggering signal.

14. The method according to claim 13, wherein the decision criterion being fulfilled if:

an examined pulse magnitude measure of a given pulse shape parameter is below a threshold value calculated based on the initial pulse magnitude measure; and

a predetermined amount of the pulse magnitude measures of the pulse shape parameters, received within a test period after the registering of the given pulse shape parameter, are below the threshold value.

15. The method according to claim 14, wherein the predetermined amount is a value representing approximately 50% to approximately 100% of the pulse magnitude measures of the pulse shape parameters received within the test period.

16. The method according to claim 14, wherein the predetermined amount representing all the pulse magnitude measures of the pulse shape parameters received within the test period.

17. The method according to claim 14, wherein the test period is an interval selected from a range extending from approximately three minutes to approximately fifteen minutes.

18. The method according to claim 17, wherein the test period is approximately five minutes long.

19. The method according to claim 14, wherein the threshold value is calculated by:

normalizing the initial pulse magnitude measure, and

dividing the normalized initial pulse magnitude measure by a predefined denominator.

20. The method according to claim 19, wherein, during the measurement period, a pulse magnitude measure is calculated for a received pulse shape parameter by dividing an original measure with the initial pulse magnitude measure.

21. The method according to claim 20, wherein the predefined denominator being a value selected from a range extending from approximately 1 to approximately 5.

22. The method according to claim 13, further comprising:

registering a bio-impedance parameter representing a degree of contraction of the subject'"'"'s capillary blood vessels at repeated occasions; and

investigating whether the bio-impedance parameter fulfills an auxiliary alarm criterion, and if the auxiliary alarm criterion is fulfilled;

generating the alarm triggering signal.

23. A computer program directly loadable into the internal memory of a computer, comprising software for controlling the steps of claim 13 when said program is run on the computer.

24. A computer readable medium, having a program recorded thereon, where the program is to make a computer control the steps of claim 13.