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TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY

  • US 20090274626A1
  • Filed: 01/29/2008
  • Published: 11/05/2009
  • Est. Priority Date: 07/29/2005
  • Status: Abandoned Application
First Claim
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1. A method for modulating proliferation of tumor cells, wherein the cells express TNF-α

  • Converting enzyme (TACE), the method comprising the steps of;

    (a) contacting a tumor cell with a TACE inhibitor, and(b) contacting the cell with a compound that inhibits epidermal growth factor receptor (EGFR) tyrosine kinase,whereby the TACE inhibitor enhances the sensitivity of the cell to the compound of step (b).

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