TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
First Claim
Patent Images
1. A method for modulating proliferation of tumor cells, wherein the cells express TNF-α
- Converting enzyme (TACE), the method comprising the steps of;
(a) contacting a tumor cell with a TACE inhibitor, and(b) contacting the cell with a compound that inhibits epidermal growth factor receptor (EGFR) tyrosine kinase,whereby the TACE inhibitor enhances the sensitivity of the cell to the compound of step (b).
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the EGFR tyrosine kinase inhibitor. Additionally, methods for treating cancer and methods for identifying TACE inhibitors is also provided.
-
Citations
25 Claims
-
1. A method for modulating proliferation of tumor cells, wherein the cells express TNF-α
- Converting enzyme (TACE), the method comprising the steps of;
(a) contacting a tumor cell with a TACE inhibitor, and (b) contacting the cell with a compound that inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the compound of step (b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- Converting enzyme (TACE), the method comprising the steps of;
- 13. A method of treating cancer comprising administering to a mammal in need thereof a therapeutically effective amount of a TACE inhibitor and a therapeutically effective amount of an EGFR tyrosine kinase inhibitor, whereby the TACE inhibitor enhances the sensitivity of a cell to the EGFR tyrosine kinase inhibitor.
-
19. A method of identifying a TACE inhibitor that sensitizes a tumor cell to an EGFR tyrosine kinase inhibitor, the method comprising the steps of:
-
(a) contacting a tumor cell with a compound suspected of being a TACE inhibitor, (b) contacting the tumor cell with an EGFR tyrosine kinase inhibitor, and (c) determining tumor cell proliferation, whereby the compound that enhances the sensitivity of the tumor to the EGFR tyrosine kinase inhibitor is identified as a TACE inhibitor that sensitizes a tumor cell to an EGFR tyrosine kinase inhibitor. - View Dependent Claims (20, 21, 22, 23, 24, 25)
-
Specification