×

SOLID PHARMACEUTICAL COMPOSITION WITH A FIRST FRACTION OF A DISPERSION MEDIUM AND A SECOND FRACTION OF A MATRIX, THE LATTER BEING AT LEAST PARTIALLY FIRST EXPOSED TO GASTROINTESTINAL FLUIDS

  • US 20090274759A1
  • Filed: 06/02/2006
  • Published: 11/05/2009
  • Est. Priority Date: 06/03/2005
  • Status: Abandoned Application
First Claim
Patent Images

1. A coated solid pharmaceutical composition in the form of a single dosage unit for oral use, the composition comprising a first and a second fraction,i) the first fraction comprises a therapeutically and/or prophylactically active substance dispersed in a dispersion medium that is sufficiently fluid at body temperature,wherein the first fraction is placed between two second fractions, between a coating and a second fraction, or alternatively is completely surrounded by a second fraction, the first fraction has a melting point cut off of at the most about 38°

  • C., andthe active substances contained in the first fraction is released relatively fast once the second fraction has eroded, andii) the second fraction comprises an erodable matrix comprising a substantially water soluble or crystalline polymer or a mixture of substantially water soluble and/or crystalline polymers, the polymer being a polyethylene oxide having a MW of from 20,000 daltons to about 700,000 or a block copolymer of ethylene oxide and propylene oxide having a MW of from about 3,000 to about 30,000 daltons, or a mixture thereof,wherein the composition is coated with a coating having at least one opening exposing one surface of the matrix of the second fraction, and the coating is substantially insoluble in and impermeable to body fluids.

View all claims
  • 7 Assignments
Timeline View
Assignment View
    ×
    ×