Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus
First Claim
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1. A method of diagnosing an increased susceptibility to type II diabetes in an individual, comprising detecting a marker or haplotype associated with the exon 4 LD block of TCF7L2 in the individual, wherein the presence of the marker or haplotype is indicative of an increased susceptibility to type II diabetes.
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Abstract
Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.
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25 Claims
- 1. A method of diagnosing an increased susceptibility to type II diabetes in an individual, comprising detecting a marker or haplotype associated with the exon 4 LD block of TCF7L2 in the individual, wherein the presence of the marker or haplotype is indicative of an increased susceptibility to type II diabetes.
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4. A method of assessing an individual for probability of response to a TCF7L2 therapeutic agent, comprising:
- detecting a marker associated with the exon 4 LD block of TCF7L2, wherein the presence of the marker is indicative of a probability of a positive response to a TCF7L2 therapeutic agent.
- View Dependent Claims (5, 6, 7)
- 8. A method of diagnosing a decreased susceptibility to type II diabetes in an individual, comprising detecting a marker or haplotype associated with the exon 4 LD block of TCF7L2 in the individual, wherein the presence of the marker or haplotype is indicative of a decreased susceptibility to type II diabetes.
- 10. A method of detecting an increased susceptibility to type II diabetes in an individual, comprising identifying the presence or absence of an allele at a marker associated with the exon 4 LD block of TCF7L2 in the individual, wherein identification of the presence of the allele is indicative of increased susceptibility to type II diabetes in the individual.
- 14. A method of detecting a decreased susceptibility to type II diabetes in an individual, comprising identifying the presence or absence of an allele at a marker associated with the exon 4 LD block of TCF7L2 in the individual, wherein identification of the presence of the allele is indicative of decreased susceptibility to type II diabetes in the individual.
- 18. A method of detecting an increased susceptibility to type II diabetes in an individual, comprising detecting an allele at a polymorphism associated with the exon 4 LD block of TCF7L2 in the individual, wherein identification of said allele at the polymorphism is indicative of increased risk of type II diabetes in the individual.
- 22. A method of detecting a decreased susceptibility to type II diabetes in an individual, comprising detecting an allele at a polymorphism associated with the exon 4 LD block of TCF7L2 in the individual, wherein identification of said allele at the polymorphism is indicative of decreased risk of type II diabetes in the individual.
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