METHOD FOR DETECTING MAMMARY CANCER CELLS

• US 20090275045A1
• Filed: 07/14/2009
• Published: 11/05/2009
• Est. Priority Date: 02/01/2007
• Status: Abandoned Application

• Current Assignee: Oriental Yeast Company Limited (Nisshin Seifun Group Incorporated)
• Original Assignee: Oriental Yeast Company Limited (Nisshin Seifun Group Incorporated)
• Inventors: Uchida, Koji, Sugimoto, Michiyo, Kinugasa, Masahiro
• Application Number:
  US12/502,718
• Publication Number:
  US 20090275045A1
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: G01N 33/57415 of breast

Abstract

The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2).

Claims

1. A method for detecting mammary cancer cells, comprising:

detecting mammary cancer cells on the basis of a difference in expression level of a marker gene between human mammary cancer tissue (or cells) and normal mammary gland tissue (or cells).

2. The method according to claim 1, wherein the expression level of the marker gene is indicated by an amount of mRNA transcribed therefrom.

3. The method according to claim 1, wherein the marker gene is at least one selected from the group consisting of genes having nucleotide sequences of GenBank accession Nos. BC071926, AC005028, AY424280, BC070036, BC041424, BC050454, AC068213, BC016981, AL138808, AJ505757, BC033015, BC015523, AL110326 and BC065198 and homologs thereof.

4. The method according to claim 1, wherein the expression level of the marker gene in the mammary cancer tissue (or cells) is twice or more or ½

or less than that in the normal mammary gland tissue (or cells).