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BIOMIMETIC NUCLEIC ACIDS

  • US 20090275130A1
  • Filed: 05/02/2009
  • Published: 11/05/2009
  • Est. Priority Date: 05/02/2008
  • Status: Abandoned Application
First Claim
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1. A method for generating biomimetic nucleic acids comprising:

  • a) contacting a library of nucleic acids with a target molecule;

    b) partitioning non-binding members to said target molecule of said library from binding members to said target biomolecule of said library;

    c) selectively displacing the binding member to said target biomolecule utilizing at least a molecule that natively binds to said target molecule;

    d) collecting displaced binding members of the library;

    e) applying said displaced binding members of the library from step d to said target and repeating steps c and d for a selected number of rounds of selection; and

    f) screening members of the library remaining from said number of rounds of selection for functional activity against said target molecule in comparison to said molecule that natively binds to said target.

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