SYSTEM AND METHOD OF MONITORING PHYSIOLOGIC PARAMETERS BASED ON COMPLEX IMPEDANCE WAVEFORM MORPHOLOGY

• US 20090275854A1
• Filed: 04/30/2008
• Published: 11/05/2009
• Est. Priority Date: 04/30/2008
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Hettrick, Douglas A., Warman, Eduardo N., Zielinski, Todd M.
• Application Number:
  US12/112,655
• Publication Number:
  US 20090275854A1
• Time in Patent Office: Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

Changes in physiologic parameters may be detected in a patient by measuring the impedance of a tissue segment located in a selected electrode vector field, storing baseline impedance information based on the measured impedance, detecting changes in impedance characteristics from the baseline impedance information, and providing alerts for changes in the physiologic parameters based on the detected changes in impedance characteristics. In some situations, detecting the changes in impedance characteristics involves detecting changes in morphology of an impedance waveform, such as a cardiac component of an impedance waveform, a respiratory component of an impedance waveform, and the phase angle of the complex impedance.

Claims

1. A method of monitoring physiologic parameters in a patient, the method comprising:

measuring impedance of a tissue segment located in a selected electrode vector field;

storing baseline impedance information based on the measured impedance;

detecting changes in impedance characteristics from the baseline impedance information; and

providing alerts indicating changes in the physiologic parameters based on the detected changes in impedance characteristics.

2. A method according to claim 1, wherein measuring the impedance of the tissue segment in the selected electrode vector field comprises measuring a real component and a reactive component of the impedance.

3. A method according to claim 1, wherein detecting changes in impedance characteristics from the baseline impedance information includes detecting changes in morphology of an impedance waveform.

4. A method according to claim 1, further comprising filtering the measured impedance of the tissue segment to isolate a cardiac component of the impedance.

5. A method according to claim 4, wherein the baseline impedance information includes at least one of a minimum impedance, a maximum impedance, a minimum-to-maximum impedance difference, a maximum positive rate of change of impedance, a minimum negative rate of change of impedance, a mean impedance, and a time interval between impedance peaks.

6. A method according to claim 5, wherein the physiologic parameters include at least one of left ventricle end diastolic volume at end expiration, left ventricle end systolic volume at end expiration, stroke volume, left ventricle lusitropic function/relaxation, left ventricle inotropic contractility, fluid status in the electrode vector field, and heart rate.

7. A method according to claim 1, further comprising filtering the measured impedance of the tissue segment to isolate a respiratory component of the impedance.

8. A method according to claim 7, wherein the baseline impedance information includes at least one of an impedance magnitude at end expiration, an impedance magnitude at end inspiration, a minimum negative rate of change of impedance during expiration, a maximum positive rate of change of impedance during inspiration, a time interval between impedance peaks, a minimum-to-maximum impedance during a respiratory cycle, and an area under an impedance waveform during a respiratory cycle.

9. A method according to claim 8, wherein the physiologic parameters include at least one of positive intrathoracic pressure during expiration, negative intrathoracic pressure during inspiration, thoracic cavity compliance (recoil), thoracic cavity compliance (stretch), respiratory rate, respiratory effort, and tidal volume.

10. A method according to claim 1, further comprising determining a phase angle of the measured impedance of the tissue segment.

11. A method according to claim 10, wherein the baseline impedance information includes at least one of a minimum phase angle, a maximum phase angle, a minimum-to-maximum phase angle difference, a minimum negative rate of change of phase angle, a maximum positive rate of change of phase angle, and a time interval between phase angle peaks.

12. A method according to claim 11, wherein the physiologic parameters include at least one of atrial contraction at left ventricle end diastole, left ventricle contraction at end systole, left ventricle contraction as reflected by ejection time, left ventricle lusitropic function/relaxation, inotropic contractility of the left ventricle, and heart rate.

13. A method according to claim 1, wherein measuring the impedance of the tissue segment located in the selected electrode vector field comprises:

positioning a plurality of electrodes in the patient cutaneously, subcutaneously, intravascularly, intracardially, or any combination of these;

injecting a current between selected electrodes of the plurality of electrodes; and

measuring a voltage between selected electrodes of the plurality of electrodes to determine an impedance of a tissue segment located in the electrode vector field therebetween as a function of the injected current and the measured voltage.

14. A method according to claim 1, further comprising adjusting or delivering therapy based on alerts provided to indicate changes in the physiologic parameters.

15. A method of monitoring a physiologic parameter in a patient, the method comprising:

positioning a plurality of electrodes in the patient cutaneously, subcutaneously, intravascularly, intracardially, or any combination of these;

selecting an electrode vector from the plurality of electrodes to create an electrode vector field that includes a tissue segment such that a change in impedance in the electrode vector field reflects a change in the physiologic parameter being monitored;

measuring impedance of the tissue segment located in the selected electrode vector field;

storing baseline impedance information based on the measured impedance;

detecting changes in impedance characteristics from the baseline impedance information; and

providing alerts indicating changes in the physiologic parameters based on the detected changes in impedance characteristics.

16. A method according to claim 15, wherein measuring impedance of the tissue segment in the selected electrode vector field comprises measuring a real component and a reactive component of the impedance.

17. A method according to claim 15, wherein measuring the impedance of the tissue segment located in the selected electrode vector field comprises:

injecting a current between the selected electrodes of the plurality of electrodes; and

measuring a voltage between the selected electrodes to determine the impedance of the tissue segment located in the electrode vector field therebetween as a function of the injected current and the measured voltage.

18. A method according to claim 15, wherein detecting changes in impedance characteristics from the baseline impedance information includes detecting changes in morphology of an impedance waveform.

19. A method according to claim 15, further comprising filtering the measured impedance of the tissue segment to isolate a cardiac component of the impedance, wherein the baseline impedance information includes at least one of:

a minimum impedance, a maximum impedance, a minimum-to-maximum impedance difference, a maximum positive rate of change of impedance, a minimum negative rate of change of impedance, a mean impedance, and a time interval between impedance peaks, and

the physiologic parameter comprises at least one of;

a left ventricle end diastolic volume at end expiration, a left ventricle end systolic volume at end expiration, a stroke volume, a left ventricle lusitropic function/relaxation, a left ventricle inotropic contractility, a fluid status in the electrode vector field, and a heart rate.

20. A method according to claim 15, further comprising filtering the measured impedance of the tissue segment to isolate a respiratory component of the impedance, wherein the baseline impedance information includes at least one of:

an impedance magnitude at end expiration, an impedance magnitude at end inspiration, a minimum negative rate of change of impedance during expiration, a maximum positive rate of change of impedance during inspiration, a time interval between impedance peaks, a minimum-to-maximum impedance during a respiratory cycle, and an area under an impedance waveform during a respiratory cycle, and

the physiologic parameter comprises at least one of;

a positive intrathoracic pressure during expiration, a negative intrathoracic pressure during inspiration, a thoracic cavity compliance (recoil), a thoracic cavity compliance (stretch), a respiratory rate, a respiratory effort, and a tidal volume.

21. A method according to claim 15, further comprising determining a phase angle of the measured impedance of the tissue segment, wherein the baseline impedance information includes at least one of a minimum phase angle, a maximum phase angle, a minimum-to-maximum phase angle difference, a minimum negative rate of change of phase angle, a maximum positive rate of change of phase angle, and a time interval between phase angle peaks, and the physiologic parameter comprises at least one of atrial contraction at left ventricle end diastole, left ventricle contraction at end systole, left ventricle contraction as reflected by ejection time, left ventricle lusitropic function/relaxation, inotropic contractility of the left ventricle, and heart rate.

22. A method according to claim 15, further comprising adjusting or delivering therapy based on alerts provided to indicate changes in the physiologic parameter.

23. An apparatus for monitoring physiologic parameters in a patient, comprising:

means for measuring impedance of a tissue segment located in a selected electrode vector field;

means for storing baseline impedance information based on the measured impedance;

means for detecting changes in impedance characteristics from the baseline impedance information; and

providing alerts indicating changes in the physiologic parameters based on the detected changes in impedance characteristics.

24. An apparatus according to claim 23, wherein the means for measuring the impedance of the tissue segment in the selected electrode vector field comprises means for measuring a real component and a reactive component of the impedance.

25. An apparatus according to claim 23, wherein the means for detecting changes in impedance characteristics from the baseline impedance information includes means for detecting changes in morphology of an impedance waveform.

26. An apparatus according to claim 23, further comprising means for filtering the measured impedance of the tissue segment to isolate a cardiac component of the impedance.

27. An apparatus according to claim 26, wherein the baseline impedance information includes at least one of:

a minimum impedance, a maximum impedance, a minimum-to-maximum impedance difference, a maximum positive rate of change of impedance, a minimum negative rate of change of impedance, a mean impedance, and a time interval between impedance peaks.