METHODS OF TREATING DISEASES WHICH ARE MEDIATED BY CUTANEOUS LYMPHOCYTE ANTIGEN POSITIVE CELLS
First Claim
1. A method of treating a skin disorder characterized by cutaneous lymphocyte antigen positive T cells comprising administering an antibody or antibody fragment to a mammal with the skin disorder wherein the antibody or antibody fragment specifically binds to the polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 2, wherein the skin disorder is selected from Drug induced delayed type cutaneous allergic reactions;
Toxic epidermal necrolysis;
Cutaneous T cell Lymphoma;
Bullous pemphigoid;
Alopecia aereata;
Vitiligo;
Acne Rosacea;
Prurigo nodularis; and
Herpes simplex virus and whereby the skin disorder is improved, inhibited, or reduced.
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Abstract
The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.
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Citations
17 Claims
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1. A method of treating a skin disorder characterized by cutaneous lymphocyte antigen positive T cells comprising administering an antibody or antibody fragment to a mammal with the skin disorder wherein the antibody or antibody fragment specifically binds to the polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 2, wherein the skin disorder is selected from Drug induced delayed type cutaneous allergic reactions;
Toxic epidermal necrolysis;
Cutaneous T cell Lymphoma;
Bullous pemphigoid;
Alopecia aereata;
Vitiligo;
Acne Rosacea;
Prurigo nodularis; and
Herpes simplex virus and whereby the skin disorder is improved, inhibited, or reduced. - View Dependent Claims (2, 3, 4, 5, 6)
- 2, wherein the skin disorder is selected from Drug induced delayed type cutaneous allergic reactions;
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7. A method of improving, inhibiting, or reducing at least one symptom associated with a skin disorder characterized by cutaneous lymphocyte antigen positive T cells comprising administering an antibody or antibody fragment to a mammal wherein the at least one symptom is selected from the group consisting of:
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a) blisters; b) acne; c) lichenified or excoriated nodules; and d) erythematopapular skin lesions and hypereosinophilia and wherein the antibody or antibody fragment specifically binds to the polypeptide comprising the amino acid sequence as shown in SEQ ID NO;
2.- View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification