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COMPOSITIONS AND METHODS FOR INHIBITING TOXIN A FROM CLOSTRIDIUM DIFFICILE

  • US 20090280134A1
  • Filed: 05/11/2009
  • Published: 11/12/2009
  • Est. Priority Date: 05/09/2008
  • Status: Abandoned Application
First Claim
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1. A method for preventing or alleviating a symptom of bacterial toxin infection in a subject in need thereof, the method comprising administering to the subject fusion polypeptide comprising a first polypeptide linked to a second polypeptide, wherein the first polypeptide:

  • (a) is a mucin polypeptide; and

    (b) is glycosylated by an α

    1,3 galactosyltranserase and a β

    1,6, N-acetylglucosaminyltransferase; and

    the second polypeptide comprises at least a region of an immunoglobulin polypeptide.

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