Coating systems for the controlled delivery of hydrophilic bioactive agents
First Claim
Patent Images
1. A coating system of the invention comprising (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents;
- and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer.
2 Assignments
0 Petitions
Accused Products
Abstract
Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
-
Citations
28 Claims
-
1. A coating system of the invention comprising (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents;
- and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
26. A method for preparing a coating system for the controlled release of a hydrophilic bioactive agent, the method comprising the steps of:
- (a) providing a basecoat coating composition comprising a basecoat polymer and at least one hydrophilic bioactive agent;
(b) disposing the coating composition on the surface of a substrate to form a basecoat layer;
(c) providing a topcoat composition comprising poly(ethylene-co-vinyl acetate) copolymer; and
(d) disposing the topcoat composition over at least a portion of the basecoat layer to form the coating system. - View Dependent Claims (27, 28)
- (a) providing a basecoat coating composition comprising a basecoat polymer and at least one hydrophilic bioactive agent;
Specification