Pharmaceutical Compositions Comprising Dextran With A Molecular Weight Of 1.0-100 KDA And Processes For Their Preparation
First Claim
1. A process for preparing a composition suitable for the controlled release, in the body of a mammal, of a biologically active protein, comprising:
- (a) providing an aqueous solution of dextran having a molecular weight of 1-100 kDa at a concentration within the range of 25-75% by weight;
(b) introducing a biologically active protein into the aqueous solution of (a) to form a liquid composition; and
(c) bringing said liquid composition to a solid form by gradually eliminating water from said liquid composition by evaporation or extraction.
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Accused Products
Abstract
A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa and introducing the liquid composition into the body of a mammal, whereby the implant is formed in situ in the body of the mammal. A process for preparing a composition useful for biomedical application, comprising the steps of providing a liquid composition comprising an aqueous solution of dextran having a molecular weight of 1-100 kDa; and bringing the liquid composition to solidify; whereby water is gradually eliminated from the liquid composition during the solidification. A biomedical article prepared from the composition.
6 Citations
19 Claims
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1. A process for preparing a composition suitable for the controlled release, in the body of a mammal, of a biologically active protein, comprising:
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(a) providing an aqueous solution of dextran having a molecular weight of 1-100 kDa at a concentration within the range of 25-75% by weight; (b) introducing a biologically active protein into the aqueous solution of (a) to form a liquid composition; and (c) bringing said liquid composition to a solid form by gradually eliminating water from said liquid composition by evaporation or extraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification