Appartus and Method for Continuous Real-Time Trace Biomolecular Sampling, Analysis, and Delivery

• US 20090281404A1
• Filed: 12/09/2005
• Published: 11/12/2009
• Est. Priority Date: 12/09/2004
• Status: Active Grant

• Current Assignee: Cambridge Medical Technologies, LLC, Medina Isf Equity, LLC
• Original Assignee: Flexible Medical Systems, LLC
• Inventors: Paranjape, Makarand, Currie, John Frederick
• Granted Patent: US 8,364,228 B2
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A system and method for transdermal sampling wherein at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject'"'"'s stratum corneum. Methods for using a transdermal sampling system by creating capillary openings in a subject'"'"'s stratum corneum via the application of a series of voltage pulses to the stratum corneum and contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings are also presented.

Claims

1. A system for transdermal sampling comprising:

(a) a transdermal platform comprising a flexible substrate on which at least one pair of sample electrodes are joined by a resistive element; and

(b) an enzyme anchor layer covering at least part of at least one of the sample electrodes,

wherein said at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject'"'"'s stratum corneum.

2. A method for transdermal sampling comprising:

(a) applying to a subject in need thereof a transdermal platform comprising a flexible substrate on which at least one pair of sample electrodes are joined by a resistive element, and an enzyme anchor layer covering at least part of at least one of the sample electrodes;

(b) creating capillary openings in the subject'"'"'s stratum corneum by applying a series of voltage pulses to the stratum corneum via said at least one pair of sample electrodes; and

(c) contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings.