APPARATUS AND METHODS FOR MAPPING RETINAL FUNCTION
First Claim
1. An electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye, the device comprising:
- a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye;
at least 5 recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the cornea of the eye when the lens substrate is placed on the anterior surface of the eye;
wherein each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each electrode, each conductive contact being adapted for operable connection to a signal processor, and each conductive contact being electrically insulated from the anterior surface of the eye.
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Abstract
The present invention provides an electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye. The device comprises a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye, and at least five recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the eye when the lens substrate is placed on the anterior surface of eye. Each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each recording electrode. Each conductive contact is adapted for operable connection to signal processor, and each conductive contact is electrically insulated from the anterior surface of the eye. A computational method for analyzing electrophysiological potentials recorded at five or more locations on the anterior surface of the eye, which reflect the spatial distribution of activity of the retina, is also provided.
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Citations
24 Claims
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1. An electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye, the device comprising:
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a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye;
at least 5 recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the cornea of the eye when the lens substrate is placed on the anterior surface of the eye;
wherein each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each electrode, each conductive contact being adapted for operable connection to a signal processor, and each conductive contact being electrically insulated from the anterior surface of the eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for simultaneously recording electrophysiological potentials from five or more locations on the anterior surface of the eye of a subject comprising:
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contacting the anterior surface of the eye with an electrode array device comprising a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye;
wherein the substrate comprises at least 5 recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the eye;
each electrode being electrically connected to a signal processor including an amplifier, and capable of amplifying and detecting electrical potential signals; and
recording an electric potential signal from each electrode.
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19. A computational method for analyzing electrophysiological potentials recorded at the anterior surface of the eye which reflect activity of a retina of an eye, comprising:
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determining underlying spatially differentiated electrophysiological activity of the retina by comparing recorded eye surface potential data to estimated eye surface potentials obtained from a computational model of electrical and anatomical properties of the eye or the eye and head, the model incorporating electrical parameters and dimensions for multiple ocular structures, including at least the tear film, cornea, aqueous humor, lens, vitreous humor, retina, R-membrane, sclera, and extraocular adipose tissue;
wherein the eye surface potential data comprises at least 5 spatially differentiated electrical potentials simultaneously measured with an array of recording electrodes at predetermined electrode positions on the anterior surface of the eye. - View Dependent Claims (20, 21, 22, 23, 24)
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Specification