ELECTROPORATION DEVICE AND METHOD
First Claim
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1. A tissue treatment device comprising:
- a means for treating tissue using non-thermal irreversible electroporation, wherein the means comprises a probe havinga proximal end and a distal end;
at least a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has first voltage delivery region capable of delivering a voltage for irreversible electroporation;
at least a second voltage delivery member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage delivery member has a second voltage delivery region capable of delivering a voltage for irreversible electroporation; and
at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member.
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Abstract
Disclosed herein are methods and devices configured for pulsed voltage ablation that have two or more voltage delivery regions separated along a probe by electrically insulating regions. The electrically insulating regions are of sufficient lengths to allow the voltage delivery regions to be oppositely energized for delivering voltage pulses to treat cells within a predetermined ablation volume that can be delineated through representations indicating pulsed voltage ablation thresholds for cells.
247 Citations
46 Claims
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1. A tissue treatment device comprising:
a means for treating tissue using non-thermal irreversible electroporation, wherein the means comprises a probe having a proximal end and a distal end; at least a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has first voltage delivery region capable of delivering a voltage for irreversible electroporation; at least a second voltage delivery member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage delivery member has a second voltage delivery region capable of delivering a voltage for irreversible electroporation; and at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A tissue treatment device comprising:
a means for treating tissue using non-thermal irreversible electroporation, wherein the means comprises a probe having a proximal end and a distal end; a blunt tip disposed at the distal end of the probe; a handle disposed at the proximal end of the probe; a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has a first voltage delivery region capable of delivering a voltage for irreversible electroporation; and a second voltage delivery member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage delivery member has a second voltage delivery region capable of delivering a voltage for irreversible electroporation; and at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member.
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27. A tissue treatment device comprising:
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a probe having a proximal end and a distal end; a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has a first voltage delivery region; and a second voltage delivery member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage delivery member has a second voltage delivery region; and at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member; a blunt tip disposed at the distal end of the probe; and a handle disposed at the proximal end of the probe, wherein the handle has a proximal end and a distal end and a handle body. - View Dependent Claims (28, 29, 30)
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31. A tissue treatment device comprising:
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a first probe having a proximal end and a distal end; a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has a first voltage delivery region; and a first blunt tip disposed at the distal end of the probe; and a first handle disposed at the proximal end of the probe, wherein the first handle has a proximal end and a distal end and a first handle body. a second probe having a second voltage delivery member disposed along the entire length of the probe, wherein the second voltage delivery member has a second voltage delivery region; and a second blunt tip disposed at the distal end of the probe; and a second handle disposed at the proximal end of the probe, wherein the handle has a proximal end and a distal end and a second handle body. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 46)
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32. A method of tissue treatment using irreversible electroporation, comprising:
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providing a tissue treatment device wherein the device comprises; a proximal end a distal end; a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has a first voltage delivery region capable of delivering a voltage for irreversible electroporation of a selected volume of tissue; and a second voltage delivered member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage delivery member has a second voltage delivery region capable of delivering a voltage for irreversible electroporation; and at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member; positioning the device within the selected volume of tissue; delivering pulsed electric field gradients to the selected volume of tissue; and ablating the selected volume of tissue using non-thermal irreversible electroporation.
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44. A method of tissue treatment, comprising:
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providing a tissue treatment device wherein the device comprises; a probe having a proximal end and a distal end; a first voltage delivery member disposed along the entire length of the probe, wherein the first voltage delivery member has a first voltage delivery region; and a second voltage delivery member disposed along the probe and positioned coaxially in relation to the first voltage delivery member, wherein the second voltage deliver member has a second voltage delivery region; and at least one electrically insulating region coaxially disposed in relation to the first voltage delivery member probe, a blunt tip disposed at the distal end of the probe; and a handle disposed at the proximal end of the probe, wherein the handle has a proximal end and a distal end and a handle body; positioning the device within the selected volume of tissue; delivering pulsed electric field gradients to the selected volume of tissue; and ablating the selected volume of tissue using non-thermal irreversible electroporation.
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Specification