DEVICE FOR AUTOMATIC ADJUSTMENT OF THE DOSE OF MELATONIN AND/OR DELIVERY OF MELATONIN

• US 20090281518A1
• Filed: 09/04/2007
• Published: 11/12/2009
• Est. Priority Date: 09/13/2006
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Ackermans, Paul A.J., Krijnsen, Hendrika C., Iordanov, Ventzeslav P., Langereis, Geert, Van Bruggen, Michel P.B.
• Application Number:
  US12/440,590
• Publication Number:
  US 20090281518A1
• Time in Patent Office: Days
• US Class Current: 604/503
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

The invention relates to a device for melatonin treatment involving an adapting means which adapts the daily dose upon measurement of a body parameter of the patient or the user of the device.

Claims

1. A device for automatic adjustment of the dose of melatonin and/or delivery of melatonin, comprising

a) a measuring means, which measures at least one body parameter of a patient for at least ≧

1 measuring cycle;

b) an adapting means, which adapts and/or changes the dose of melatonin according to the measuring data of the measuring means;

c) a delivery device for delivering melatonin to a person to be treated and/or a user of the device.

2. The device according to claim 1, wherein the at least one body parameter includes body temperature, core body temperature, skin surface temperature, activity, melatonin level, cortisol level, heart rate, breathing frequency.

3. The device according to claim 1, wherein the daily dose of melatonin is set to be

previous dose+Δ

melatonin [Δ

m],

with previous dose being the daily dose of the previous day, whereby Δ

m is changed and/or set each time period, at least every 14 days, preferably at least every week, but most preferably daily (or for the next time period) in accordance with the data of the measuring means.

4. The device according to claim 1, wherein Δ

m is ≦

50 μ

g/day, preferably ≦

40 μ

g/day

5. The device according to claim 1 wherein Δ

m is set as

Δ

m≧

[Δ

mmax*(ratio−

a)/(1−

a)]*0.8 and ≦

[Δ

maxmelatonin*(ratio−

a)/(1−

a)]*1.2

with Δ

mmax being the maximum dosage change of melatonin,

ratio being the actual ratio between nocturnal and diurnal activity, and

a being the desired ratio between nocturnal and diurnal activity.

6. The device according to claim 1, whereby the amount of melatonin delivered is decreased when the ratio and a have differed ≦

0.1 (i.e. that |ratio−

a| is ≦

0.1), preferably ≦

0.05 for at least one measurement cycle, preferably for at least 5 measurement cycles, the amount of decrease being preferably ≦

20% per day and ≧

5% per day of the dosage of the previous day until m (melatonin dosage) is ≦

2.5 μ

g/day, preferably ≦

1.0 μ

g/day.

7. The device according to claim 1 wherein the delivery of melatonin occurs along a drug delivery profile.

8. The device according to claim 1 wherein the adapting means is able to take into account information supplied by the person to be treated and/or a user of the device.

10. A system incorporating a device according to claim 1 and being used in one or more of the following applications:

Medical devices for the automatic adjustment of and/or delivery of melatonin;

Jet-lag treatment devices.

9. A method for the controlled release of drugs, comprising the steps of:

a) measuring at least one body parameter of the patient for at least ≧

1 measuring cycle;

b) adapting and/or changing the dose of melatonin according to the measuring data of the measuring means;

c) delivering melatonin to a person to be treated and/or a user of the device.