IRREVERSIBLY-INACTIVATED PEPSINOGEN FRAGMENTS FOR MODULATING IMMUNE FUNCTION
First Claim
1. An method of modulating immune activity comprising administering to a patient an effective amount of a composition comprising an inactivated pepsin fragment (IPF).
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Accused Products
Abstract
Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; and NXVPVSVEGYXQITLDSITX and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
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Citations
15 Claims
- 1. An method of modulating immune activity comprising administering to a patient an effective amount of a composition comprising an inactivated pepsin fragment (IPF).
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14. A method for treating HIV infection in human patients, said method comprising the step of administering to a patient a composition comprising SEQ ID:
- NO. 6 combined with IL-2
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15. A therapeutic composition for treating HIV infection in human patients comprising a complex of the IPF fragment characterized by SEQ ID NO. 6 bound to human gp41.
Specification