HIGHLY CONCENTRATED STABILIZED IGM SOLUTION
First Claim
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1. A solution wherein a high concentration of immunoglobulin is stabilized, and wherein the immunoglobulin is IgM.
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Abstract
The present inventors discovered that stable and highly concentrated IgM solutions can be prepared by using, as an additive, a compound comprising a polyvalent cationic ion, such as magnesium chloride or arginine hydrochloride, to suppress IgM aggregation in solutions.
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35 Claims
- 1. A solution wherein a high concentration of immunoglobulin is stabilized, and wherein the immunoglobulin is IgM.
- 13. A method for stabilizing a solution comprising a high concentration of immunoglobulin, wherein the immunoglobulin is IgM and wherein the method comprises adding a polyvalent cationic ion to the solution.
- 24. A method for producing a solution comprising a high concentration of stabilized immunoglobulin, wherein the immunoglobulin is IgM and wherein the method comprises the step of adding a polyvalent cationic ion to the solution.
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