Stable Aqueous Cyclosporin Compositions
First Claim
Patent Images
1. An aqueous ophthalmic composition comprising:
- (a) a cyclosporin in an amount of from about 0.001% to about 1%;
(b) glycerin in an amount between about 0.1% and about 5%; and
(c) purified water;
(d) wherein the composition contains less than about 0.3% sodium chloride and less than about 0.04% sodium metabisulfite.
2 Assignments
0 Petitions
Accused Products
Abstract
An aqueous ophthalmic composition is disclosed. The composition may comprise a cyclosporin in an amount from about 0.001 to about 1%, glycerin, and purified water, wherein the composition is substantially free of NaCl and sodium bisulfite or sodium metabisulfite. The composition is useful for the treatment of ocular conditions.
-
Citations
20 Claims
-
1. An aqueous ophthalmic composition comprising:
-
(a) a cyclosporin in an amount of from about 0.001% to about 1%; (b) glycerin in an amount between about 0.1% and about 5%; and (c) purified water; (d) wherein the composition contains less than about 0.3% sodium chloride and less than about 0.04% sodium metabisulfite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A method of treating an ocular condition comprising contacting ocular tissue with an aqueous composition comprising:
-
(a) a cyclosporin in an amount of from about 0.001% to about 1%; (b) glycerin in an amount between about 0.1% to about 5%; and (c) purified water; (d) wherein the composition contains less than about 0.3% sodium chloride and less than about 0.04% sodium metabisulfite. - View Dependent Claims (19)
-
-
20. An aqueous ophthalmic composition comprising:
-
(a) a cyclosporin in an amount of 0.1%; (b) glycerin in an amount of 1.15%; (c) polyoxy 40 stearate in an amount of 7%; (d) EDTA in an amount of 0.1%; (e) boric acid in an amount of 0.095%; (f) sorbic acid in an amount of 0.22%; (g) polysorbate 80 in an amount of 0.537%; and (h) ethyl alcohol in an amount of 0.395%. (i) wherein the composition contains less than about 0.3% sodium chloride and less than about 0.04% sodium metabisulfite.
-
Specification