INTERFERON-BETA FUSION PROTEINS AND USES
First Claim
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1. An isolated polypeptide having the amino acid sequence X-Y-Z, wherein X is a polypeptide having the amino acid sequence, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta;
- Y is an optional linker moiety; and
Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta.
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Abstract
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
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Citations
19 Claims
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1. An isolated polypeptide having the amino acid sequence X-Y-Z, wherein X is a polypeptide having the amino acid sequence, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta;
- Y is an optional linker moiety; and
Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- Y is an optional linker moiety; and
- 10. A fusion protein having an amino terminal region consisting of the amino acid sequence of a glycosylated interferon-beta or a portion thereof and having a carboxy terminal region comprising at least a portion of a protein other than glycosylated interferon-beta.
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19-31. -31. (canceled)
Specification