Aneurysm Treatment Device And Method Of Use
First Claim
1. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising:
- at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between first and second ends, said cylindrical body member having at least one circumferential element between said first and said second ends defining an internal lumen in communication with said first and second ends;
wherein said at least one expandable stent is expandable between a first diameter D and a second diameter D′
wherein D′
is larger than D; and
a reactive material on a portion of the stent, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation resulting in expansion of the reactive material and resulting in a decrease in the size of some of the fenestrations such that blood flow through those fenestrations is lessened.
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Abstract
The present invention is directed to aneurysm treatment devices which are capable of being delivered to the situs of a vascular aneurysm through a catheter. The treatment devices comprise, in general, a body member formed by at least one support member and a reactive material selectively applied to the at least one support member. The body member provide support mechanical support to a weakened or otherwise incompetent blood vessel. The reactive material is capable of restricting or occluding blood flow to the aneurysm, without substantially affecting blood flow through the blood vessel.
113 Citations
25 Claims
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1. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising:
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at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between first and second ends, said cylindrical body member having at least one circumferential element between said first and said second ends defining an internal lumen in communication with said first and second ends; wherein said at least one expandable stent is expandable between a first diameter D and a second diameter D′
wherein D′
is larger than D; anda reactive material on a portion of the stent, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation resulting in expansion of the reactive material and resulting in a decrease in the size of some of the fenestrations such that blood flow through those fenestrations is lessened. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An apparatus for treating vascular aneurysms, comprising:
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at least one expandable, woven stent having fenestrations, said expandable stent further having a cylindrical body member located between a first and second end, said cylindrical body member further defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and flowing radially through said fenestrations into the aneurysm; wherein said at least one expandable stent is expandable between a first D and a second D′
wherein D′
is larger than D; anda pH reactive material interwoven with said at least one expandable, woven stent, said pH reactive material having a non-reacted state and a reacted state, wherein said pH reactive material in said reacted state is capable of increasing the resistance to blood flow through not all of said fenestrations.
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18. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus comprising:
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a helical stent that is expandable from a first diameter D to a second diameter D′
, wherein D′
is larger than D, said helical stent having an external surface and an internal lumen when expanded to its second diameter D′ and
there being at least one opening through said external surface; anda reactive material on a portion of said helical stent, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation giving rise to expansion of the reactive material and resulting in a decrease in the size of at least one opening such that blood flow through said at least one opening is lessened.
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19. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising:
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an expandable reticulated stent having a substantially cylindrical body member located between a first and second end, said cylindrical body member having at least one circumferential element between said first and said second end defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and radially out of the Internal lumen through fenestrations and into the aneurysm; said cylindrical body member formed by a plurality of support members capable of supporting vascular tissue; said cylindrical body member having a first diameter D and a second diameter D′
, wherein D′
is larger than D; anda reactive material selectively applied to some but not all of said of said support members, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation of giving rise to expansion of the reactive material and resulting in a decrease in the size of some of the fenestrations such that blood flow through those fenestrations is lessened.
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20. An apparatus for treating vascular aneurysms, comprising:
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at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between a first and second end, said cylindrical body member further defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and flowing radially through said fenestrations into the aneurysm; wherein said at least one expandable stent is expandable between a first diameter D and a second diameter D′
, wherein D′
is larger than D; anda stimulus-expandable hydrogel selectively applied to the stent adjacent to some but not all of said fenestrations, said stimulus-expandable hydrogel having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation of giving rise to expansion of the reactive material and resultant lessening the size of some of the adjacent fenestrations such that blood flow through those fenestrations is lessened. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification