REHYDRATABLE POLYSACCHARIDE PARTICLES AND SPONGE
First Claim
1. A composition comprising free-flowing rehydratable particles of substantially collagen-free dehydrothermally crosslinked polysaccharide.
3 Assignments
0 Petitions
Accused Products
Abstract
Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
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Citations
17 Claims
- 1. A composition comprising free-flowing rehydratable particles of substantially collagen-free dehydrothermally crosslinked polysaccharide.
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13. An implantable article comprising a rehydratable porous sponge comprising substantially collagen-free dehydrothermally crosslinked polysaccharide.
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14. A method for making a polysaccharide gel-forming composition, which method comprises:
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a) providing a substantially collagen-free polysaccharide solution; b) drying the solution to form a powder, and c) dehydrothermally crosslinking the powder to form free-flowing particles that will provide a polysaccharide gel when rehydrated.
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15. A method for making an implantable article, which method comprises:
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a) providing a substantially collagen-free polysaccharide solution, b) lyophilizing the solution to form a dried porous sponge, and c) dehydrothermally crosslinking the sponge, thereby forming an implantable article which will form a polysaccharide sponge when rehydrated.
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16. A method for treating mucosal tissue and other body structures, which method comprises applying thereto a gel or sponge comprising rehydrated substantially collagen-free dehydrothermally crosslinked polysaccharide.
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17. A method for converting a dry powdered composition to a gel, which method comprises:
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a) dispersing free-flowing polysaccharide particles in a biocompatible water-miscible polar dispersant, and b) combining the resulting dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel.
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Specification