CHITOSAN-CONTAINING PROTECTIVE COMPOSITION

• US 20090291912A1
• Filed: 04/23/2009
• Published: 11/26/2009
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Tijsma, Edze Jan, Vaccaro, Brian, Myntti, Matthew Franco, Gonzalez, Maria Nieves
• Granted Patent: US 8,530,632 B2
• Time in Patent Office: Days
• US Class Current: 514/55
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/718 Starch or degraded starch, e.g. amylose, amylopectin
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/7015 Drug-containing film-forming compositions, e.g. spray-on
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: C08B 37/003 Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof

Abstract

Body tissue and structures may be protected using a fluid containing a mixture of partially crosslinked polysaccharide and a further crosslinker. The mixture desirably is sprayable, forms a fluid protective layer via in situ crosslinking, desirably does not drip or run from a treatment site, and may avoid the use of more rapidly curing but potentially less bioacceptable crosslinkers at the treatment site.

Claims

1. A two-part composition, the first part comprising a partially crosslinked polysaccharide and the second part comprising a further crosslinker for the polysaccharide, wherein the polysaccharide or further crosslinker comprise chitosan or a chitosan derivative and the composition when hydrated and mixed can be delivered as a fluid through a spray applicator to provide a thin, conformal protective layer on a body temperature substantially vertical skin surface.

2. A composition according to claim 1 wherein the polysaccharide comprises chitosan or a chitosan derivative.

3. A composition according to claim 1 wherein the further crosslinker comprises chitosan or a chitosan derivative.

4. A composition according to claim 1 wherein the polysaccharide and further crosslinker comprise chitosan or a chitosan derivative.

5. A composition according to claim 1 wherein the polysaccharide or further crosslinker comprise cellulose or a cellulose derivative.

6. A composition according to claim 1 wherein the polysaccharide or further crosslinker comprise starch or a starch derivative.

7. A composition according to claim, 1 wherein the polysaccharide or further crosslinker comprise chitin, chondroitin sulfate, dextran, glycogen, hyaluronic acid or derivative thereof.

8. A composition according to claim 1 wherein the polysaccharide and further crosslinker are combined in a molar ratio of about 20:

1 to about 1;

20.

9. A composition according to claim 1 wherein the polysaccharide and further crosslinker are combined in a molar ratio of about 3:

1 to about 1;

5.

10. A composition according to claim 1 further comprising phosphate ions.

11. A composition according to claim 1 packaged in a syringe.

12. A composition according to claim 11 wherein the polysaccharide is in dry particulate form.

13. A composition according to claim 1 wherein the composition when hydrated and mixed can be spray-applied to form a thin, conformal, initially fluid protective layer on a body temperature substantially vertical skin surface, and does not drip or run from the surface when so applied.

14. A protective layer on a body temperature surface, the layer comprising an initially fluid mixture of a partially crosslinked polysaccharide and a further crosslinker for the polysaccharide, wherein the polysaccharide or further crosslinker comprise chitosan or a chitosan derivative and the partially crosslinked polysaccharide was partially crosslinked before mixture with the further crosslinker.

15. A method for treating body tissue or structure, which method comprises:

a) mixing a two-part composition, the first part comprising a partially crosslinked polysaccharide solution and the second part comprising a further crosslinker for the polysaccharide, wherein the polysaccharide or further crosslinker comprise chitosan or a chitosan derivative;

b) applying the mixed parts as a fluid directed onto the body tissue or structure to form a protective layer thereon.