DUAL OPIOID PAIN THERAPY

• US 20090291975A1
• Filed: 05/20/2009
• Published: 11/26/2009
• Est. Priority Date: 05/20/2008
• Status: Abandoned Application

• Current Assignee: Qrxpharma Ltd.
• Original Assignee: Felix A. De La Iglesia, Gary W. Pace, Maree Smith, Patricia Richards, Warren Stern
• Inventors: Pace, Gary W., Richards, Patricia, STERN, WARREN, IgLesia, Felix A. de la, Smith, Maree
• Application Number:
  US12/469,438
• Publication Number:
  US 20090291975A1
• Time in Patent Office: Days
• US Class Current: 514/282
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Provided are pharmaceutical compositions and methods for the alleviation of pain in a patient with optimal ratios of morphine and oxycodone that provide superior analgesic efficacy and lower incidence of adverse side effects compared to morphine and oxycodone alone. The pharmaceutical compositions comprise morphine and oxycodone, or pharmaceutically acceptable salts thereof, in ratios of about 3 to 2 to about 1 to 2, morphine to oxycodone by weight.

Claims

1. An analgesic pharmaceutical composition for oral administration comprising morphine and oxycodone, or pharmaceutically acceptable salts thereof, in a ratio of about 3 to 2 morphine to oxycodone by weight, optionally in combination with a pharmaceutically acceptable carrier, wherein the morphine and the oxycodone are present in amounts of about 3-200 mg morphine and about 2-200 mg oxycodone.

2. The pharmaceutical composition of claim 1, wherein the composition comprises pharmaceutically acceptable salts of morphine and oxycodone.

9. The pharmaceutical composition of claim 1, wherein the composition is in the form of a solid oral dosage form.

10. The pharmaceutical composition of claim 9, wherein the dosage form comprises an immediate release formulation.

11. The pharmaceutical composition of claim 9, wherein the dosage form comprises a controlled release formulation.

12. The pharmaceutical composition of claim 9, wherein the dosage form is a tablet or capsule.

13. The pharmaceutical composition of claim 1, wherein the dosage form is a liquid oral dosage form.

16. A method for the alleviation of pain in a patient comprising administering to the patient the pharmaceutical composition of claim 1.

33. The analgesic pharmaceutical composition of claim 1, wherein the composition comprises about 3 mg morphine and about 2 mg oxycodone.

34. The analgesic pharmaceutical composition of claim 1, wherein the composition comprises about 6 mg morphine and about 4 mg oxycodone

35. The analgesic pharmaceutical composition of claim 1, wherein the composition comprises about 12 mg morphine and about 8 mg oxycodone.

36. The analgesic pharmaceutical composition of claim 1, wherein the composition comprises about 18 mg morphine and about 12 mg oxycodone.

3-8. -8. (canceled)

14. An analgesic pharmaceutical composition for intravenous or sub-cutaneous administration comprising morphine and oxycodone, or pharmaceutically acceptable salts thereof, in a ratio of about 3 to 2 morphine to oxycodone by weight, optionally in combination with a pharmaceutically acceptable carrier, wherein the morphine and the oxycodone are present in amounts of about 3-200 mg morphine and about 2-200 mg oxycodone.

23. A method for the alleviation of pain in a patient comprising administering to the patient the pharmaceutical composition of claim 14.

15. (canceled)

17-22. -22. (canceled)

24-32. -32. (canceled)

37. An analgesic pharmaceutical composition for oral administration comprising morphine and oxycodone, or pharmaceutically acceptable salts thereof, optionally in combination with a pharmaceutically acceptable carrier, wherein the morphine and the oxycodone are present in amounts of about 6 mg morphine and about 4 mg oxycodone.

38. An analgesic pharmaceutical composition for oral administration comprising morphine and oxycodone, or pharmaceutically acceptable salts thereof, optionally in combination with a pharmaceutically acceptable carrier, wherein the morphine and the oxycodone are present in amounts of about 12 mg morphine and about 8 mg oxycodone.