Method and System for Non-Invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis
First Claim
1. A system for detecting glucose in a biological sample, comprising:
- at least one light source configured to strike a target area of a sample;
at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and
a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area with a signal-to-noise ratio of at least 20-to-1, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area.
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Accused Products
Abstract
Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting for the effect of temperature on various system components such as resistors, and (5) accounting for dark current in a light detector by performing a calibration.
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Citations
49 Claims
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1. A system for detecting glucose in a biological sample, comprising:
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at least one light source configured to strike a target area of a sample; at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area with a signal-to-noise ratio of at least 20-to-1, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area. - View Dependent Claims (2, 3, 4, 5)
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6. A system for detecting glucose in a biological sample, comprising:
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at least one light source configured to strike a target area of a sample; at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area with a normalization factor, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A system for detecting glucose in a biological sample, comprising:
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at least one light source configured to strike a target area of a sample; at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area with a ratio factor, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A system for detecting glucose in a biological sample, comprising:
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at least one light source configured to strike a target area of a sample; at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area and eliminates effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area. - View Dependent Claims (19, 20, 21)
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22. A system for detecting glucose in a biological sample, comprising:
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at least one light source configured to strike a target area of a sample; at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; and a processor that receives the output signal from the at least one light detector and based on the received output signal, calculates the attenuance attributable to blood in a sample present in the target area and eliminates effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determines a blood glucose level associated with a sample present in the target area. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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29. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light source configured to strike a target area of a sample; utilizing at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; receiving the output signal from the at least one light detector with a processor and based on the received output signal; calculating the attenuance attributable to blood in a sample present in the target area with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor. - View Dependent Claims (30, 31)
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32. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light source configured to strike a target area of a sample; utilizing at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; receiving the output signal from the at least one light detector with a processor and based on the received output signal; calculating the attenuance attributable to blood in a sample present in the target area with a normalization factor with the processor; and determining a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor. - View Dependent Claims (33, 34, 35, 36, 37)
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38. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light source configured to strike a target area of a sample; utilizing at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; receiving the output signal from the at least one light detector with a processor; calculating the attenuance attributable to blood in a sample present in the target area with a ratio factor based on the received output signal with the processor; and determining a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light source configured to strike a target area of a sample; utilizing at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected; receiving the output signal from the at least one light detector with a processor and based on the received output signal; calculating the attenuance attributable to blood in a sample present in the target area with a ratio factor with the processor; eliminating effect of uncertainty caused by temperature dependent detector response of the at least one light detector with the processor; and determining a blood glucose level associated with a sample present in the target area with the processor based on the calculated attenuance with the processor. - View Dependent Claims (45, 46, 47, 48, 49)
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Specification