Devices for Restoring Blood Flow and Embolus Removal During Acute Ischemic Stroke

• US 20090292297A1
• Filed: 05/29/2009
• Published: 11/26/2009
• Est. Priority Date: 05/19/2008
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Mindframe LLC
• Inventors: Ferrere, David
• Granted Patent: US 8,088,140 B2
• Time in Patent Office: Days
• US Class Current: 606/127
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320783 through side-hole, e.g. sliding or rotating cutter inside catheter
• CPC Class Codes: A61B 2017/22039 eccentric
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0097 Harpoon-shaped
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/09025 with sliding mandrils

Abstract

Briefly stated, improved processes and devices restore blood flow to permit auto-lysis of clots, or enable capture emboli in their entirety without fragmenting while arterial access is maintained, preserving the integrity of patients'"'"' vasculature.

Claims

1. A process for restoring blood flow and embolus removal during acute ischemic stroke, comprising in combination:

accessing an artery with a catheter system;

locating an embolic/occluded zone within a target vessel or branding contacting the subject embolus/clot with a reperfusion/clot removal device;

reperfusion the target vessel or branch by engaging the subject embolis/clot and through auto-lysis; and

removing the subject embolis/clot by withdrawing the reperfusion/clot removal device with fragmenting the same.

2. The process of claim 1, the contacting stop further comprising deploying the reperfusion/clot removal device whereby a first and of the device operatively abuts the subject embolus/clot.

3. The process of claim 2, the reperfusing step further comprising at least one of revascularizing and recanulizing the embolic/occluded zone by manipulating the device and establishing a flow path.

4. The process of claim 3, the removing step further comprising recapturing the device.

5. The process of claim 4, the removing step further comprising moving an entrapped/embolized embolus/clot down the intracranial tree to a more stable location.

6. The process of claim 5, the reperfusing step further comprising microcatheter access.

7. A product for the process of claim 1 further comprising:

at least one device selected from the group of everted, stent-like members, basket-like clot removal devices having everted distal tips, and hybrid devices of the first two-types.

8. The product of claim 7, further comprising nitinol.

9. The product of claim 8, further comprised of at least one of open and closed calls.

10. The product of claim 9, whereby the cell size is variable at different parts of said device.

11. The product of claim 10, wherein the fibrous nature of clots/emboli and cell structure facilitates clot attachment to the device.

12. An extraction device comprising, in combination:

a microcatheter,

a capturing device configured to be selectively disposed within a lumen of the microcatheter, wherein the capturing device includes an opening configured to accept passage of a clot to within the capturing device and a distal end configured to contain the clot within the capturing device.

13. The extraction device of claim 12, wherein the opening is a mouth disposed on a middle section of the capturing device.

14. The extraction device of claim 12, wherein the opening is an opening of an open-cell structure of a mesh netting that contributes to the structure of the capturing device.

15. The extraction device of claim 12, wherein the opening is an everted section on a proximal end of the capturing device.

16. The extraction device of claim 12, further comprising a guidewire.