Biomaterial for Suturing

• US 20090292311A1
• Filed: 07/31/2009
• Published: 11/26/2009
• Est. Priority Date: 08/25/2004
• Status: Abandoned Application

• Current Assignee: Cellerix S.L. (Takeda Pharmaceutical Company Limited), Universidad Autónoma de Madrid
• Original Assignee: Universidad Autónoma de Madrid
• Inventors: Miguel, Gema Fernandez, Garcia Olmo, Damian, Gonzalez de la Pena, Manuel A.
• Application Number:
  US12/533,875
• Publication Number:
  US 20090292311A1
• Time in Patent Office: Days
• US Class Current: 606/219
• CPC Class Codes: A61L 17/00 Materials for surgical sutures or for ligaturing blood vessels surgical adhesives A61L24/00; surgical instruments, devices or methods for suturing or ligaturing A61B17/04, A61B17/12; supports or packages for suture materials A61B17/04; Materials for prostheses or catheters bone cements or surgical adhesives for soft body tissues A61L24/00; shape or structure of prostheses A61F2/00; shape or structure of catheters A61M5/00
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: C12N 5/0667 Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Abstract

A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and/or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.

Claims

1-28. -28. (canceled)

29. A method of suturing, comprising the steps of:

(a) obtaining multipotent stem cells;

(b) adhering the multipotent stem cells to a thread or staple; and

(c) bringing edges of tissue together using the thread or staple.

30. The method of claim 29, wherein the multipotent stem cells are adipose derived.

31. The method of claim 30, wherein the adipose derived multipotent stem cells are obtained by liposuction.

32. The method of claim 29, wherein the population of multipotent stem cells is a heterogenous cell population.

33. The method of claim 29, wherein the thread is absorbable.

34. The method of claim 29, wherein the thread is made of a natural material.

35. The method of claim 29, wherein the thread is a monofilament.

36. A method for promoting healing of a wound, comprising the step of bringing the edges of the wound together using a thread or staple that contains multipotent stem cells.

37. The method of claim 36, wherein the multipotent stem cells are adipose derived.

38. The method of claim 37, wherein the adipose derived multipotent stem cells are obtained by liposuction.

39. The method of claim 36, wherein the population of multipotent stem cells is a heterogenous cell population.

40. The method of claim 36, wherein the population of multipotent stem cells is an autologous, allogenic, or xenogenic population or a combination thereof.

41. The method of claim 36, wherein the thread is absorbable.

42. The method of claim 36, wherein the thread is made of a natural material.

43. The method of claim 36, wherein the thread is a monofilament.

44. Use of a support material for suturing that contains multipotent stem cells.

45. The use of claim 44, comprising the steps of:

(a) obtaining multipotent stem cells;

(b) adhering the multipotent stem cells to the support material; and

(c) bringing edges of tissue together using the support material.

46. The use of claim 44, wherein the support material for suturing comprises a thread or staple.