Protein activity modification
First Claim
Patent Images
1. A method of modifying tissue behavior, comprising:
- determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation;
selecting an electric field having a known effect of modifying protein activation levels of at least one protein as an immediate response of a tissue to the field, said known effect correlated with said desired modification; and
applying said field to said tissue, wherein said tissue comprises cardiac tissue.
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Abstract
A method of modifying tissue behavior, including cardiac tissue, comprising:
- determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation;
- selecting an electric field having a known effect of modifying protein activation levels of at least one protein as an immediate response of a tissue to the field, said known effect correlated with said desired modification; and
- applying said field to said tissue.
128 Citations
92 Claims
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1. A method of modifying tissue behavior, comprising:
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determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having a known effect of modifying protein activation levels of at least one protein as an immediate response of a tissue to the field, said known effect correlated with said desired modification; and applying said field to said tissue, wherein said tissue comprises cardiac tissue. - View Dependent Claims (3, 4, 5, 7, 10, 11, 18, 19, 20, 22, 24, 25, 27, 28, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 44, 49, 50, 58, 59, 62, 63, 64, 67, 68, 69, 70, 71)
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72. Apparatus for treating tissue, comprising:
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at least one electrode adapted to apply a field to in-vivo tissue; a controller including a memory having stored therein at least one electric field sequence which modifies protein activity levels in said tissue, said controller being configured to determine that a modification of said protein activity is desired and apply said sequence in response said determination.
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91. A biochemical assaying kit, comprising:
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an indicator of protein phosphorylation. at least one electrode adapted to apply an electric field to a sample being tested with said kit; and instructions for using said phosphorylation as an indicator of tissue state.
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92-154. -154. (canceled)
Specification