Biodegradable Adhesive Hydrogels
First Claim
1. A method for adhering a first surface to a second surface with an adhesive hydrogel wherein at least one of said first surface and said second surface is a tissue surface, said method comprising:
- a) applying to said first surface a first mixture comprising at least one photosensitive molecule and at least one initiator;
b) applying to said second surface a second mixture comprising at least one macromer, at least one cross-linking agent, and at least one initiator;
c) contacting said first surface with said second surface after application of said first mixture and said second mixture; and
d) exposing said contacted surfaces to light having a wavelength sufficient to activate said photosensitive molecule, thereby forming an adhesive hydrogel and adhering said first surface to said second surface.
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Accused Products
Abstract
Disclosed are methods for forming adhesive hydrogels on tissue surfaces comprising applying to a first tissue surface at a treatment site a first mixture comprising at least one photosensitive molecule and at least one initiator, exposing the first tissue surface to light having a wavelength sufficient to activate the photosensitive molecule to form an activated tissue surface, applying to the activated tissue surface or to a second surface a second mixture comprising at least one macromer, at least one cross-linking agent, and at least one initiator and contacting the first tissue surface with the second surface thus adhering the first tissue surface to the second surface through macromer cross-linking and resulting adhesive hydrogel formation.
30 Citations
24 Claims
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1. A method for adhering a first surface to a second surface with an adhesive hydrogel wherein at least one of said first surface and said second surface is a tissue surface, said method comprising:
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a) applying to said first surface a first mixture comprising at least one photosensitive molecule and at least one initiator; b) applying to said second surface a second mixture comprising at least one macromer, at least one cross-linking agent, and at least one initiator; c) contacting said first surface with said second surface after application of said first mixture and said second mixture; and d) exposing said contacted surfaces to light having a wavelength sufficient to activate said photosensitive molecule, thereby forming an adhesive hydrogel and adhering said first surface to said second surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for forming adhesive hydrogels on tissue surfaces comprising:
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a) applying to a first tissue surface at a treatment site a first mixture comprising at least one photosensitive molecule and at least one initiator; b) applying to said first tissue surface a second mixture comprising at least one macromer, at least one cross-linking agent, and at least one initiator; and c) contacting said first tissue surface with a second surface after application of said first mixture and said second mixture; and d) exposing said contacted first tissue surface to light having a wavelength sufficient to activate said photosensitive molecule thus adhering said first tissue surface to said second surface through macromer cross-linking and resulting adhesive hydrogel formation. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification