OPTICAL LENS SYSTEM AND METHOD FOR MICROFLUIDIC DEVICES
First Claim
1. An apparatus for imaging one or more selected fluorescence indications from a microfluidic device including an array of closed reaction chambers, the apparatus comprising:
- an imaging path coupled to the array of closed reaction chambers in the microfluidic device, the imaging path providing for transmission of one or more fluorescent emission signals derived from one or more samples in the array of closed reaction chambers in the microfluidic device, each of the closed reaction chambers in the array of closed reaction chambers having a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path;
an optical lens system coupled to the imaging path, the optical lens system being adapted to transmit the one or more fluorescent signals derived from the one or more samples in the array of closed reaction chambers in the microfluidic device, wherein the optical lens system is adapted to reduce a size of the actual spatial dimension to a reduced size less than the size of the actual spatial dimension; and
a multi-pixel detector coupled to the optical lens system and adapted to receive the one or more fluorescent signals transmitted from the optical lens system.
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Abstract
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
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Citations
20 Claims
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1. An apparatus for imaging one or more selected fluorescence indications from a microfluidic device including an array of closed reaction chambers, the apparatus comprising:
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an imaging path coupled to the array of closed reaction chambers in the microfluidic device, the imaging path providing for transmission of one or more fluorescent emission signals derived from one or more samples in the array of closed reaction chambers in the microfluidic device, each of the closed reaction chambers in the array of closed reaction chambers having a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path; an optical lens system coupled to the imaging path, the optical lens system being adapted to transmit the one or more fluorescent signals derived from the one or more samples in the array of closed reaction chambers in the microfluidic device, wherein the optical lens system is adapted to reduce a size of the actual spatial dimension to a reduced size less than the size of the actual spatial dimension; and a multi-pixel detector coupled to the optical lens system and adapted to receive the one or more fluorescent signals transmitted from the optical lens system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of imaging one or more selected fluorescence indications from a microfluidic device including an array of closed reaction chambers, the method comprising:
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transmitting one or more fluorescent emission signals derived from one or more samples in the array of closed reaction chambers in the microfluidic device along an imaging path coupled to the array of closed reaction chambers in the microfluidic device, wherein each of the closed reaction chambers in the array of closed reaction chambers has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path; transmitting the one or more fluorescent emission signals derived from the one or more samples in the array of closed reaction chambers in the microfluidic device via an optical lens system coupled to the imaging path, wherein the optical lens system is adapted to reduce a size of the actual spatial dimension to a reduced size less than the size of the actual spatial dimension; and receiving the one or more fluorescent emission signals transmitted via the optical lens system at a multi-pixel detector. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification