COATINGS FOR MEDICAL DEVICES HAVING REVERSIBLE HYDROPHOBIC TO HYDROPHILIC PROPERTIES

• US 20090294732A1
• Filed: 05/29/2008
• Published: 12/03/2009
• Est. Priority Date: 05/29/2008
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Arney, Michel, Warner, Robert, Atanasoska, Liliana, Godavarti, Shankar
• Application Number:
  US12/129,038
• Publication Number:
  US 20090294732A1
• Time in Patent Office: Days
• US Class Current: 252/500
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

A medical device including a coating disposed on at least a portion of a surface of the medical device, the coating including at least one polymer material having reversible wettability.

Claims

1. A medical device comprising a coating disposed on at least a portion of a surface of said medical device, the coating comprising at least one polymer material having reversibly switchable wettability.

2. The medical device of claim 1 wherein said at least one polymer is an electronic polymer that exhibits reversibly switchable wettability upon application of different electrical potential.

3. The medical device of claim 1 wherein the electrical potential ranges from about −

0.8V to about +0.8V.

4. The medical device of claim 1 wherein said at least said portion of said surface comprising said coating has a water contact angle from 0°

to about 160°

.

5. The medical device of claim 1 wherein said surface comprising said coating has a water contact angle that is switchable from less than about 50°

to greater than about 145°

.

6. The medical device of claim 1 wherein said surface comprising said coating has a water contact angle that is switchable from less than about 5°

to greater than about 150°

.

7. The medical device of claim 1 wherein said surface comprising said coating has a water contact angle that is switchable between about 0°

-5° and

about 150-180°

.

8. The medical device of claim 1 wherein said at least one polymer material is a member selected from the group consisting of poly(acetylene)s, poly(pyrrole)s, poly(N-methyl pyrrole), poly(thiophene)s, poy(aniline)s, poly(fluorene)s, poly(3-hexylthiophene), polynaphthalenes, poly(p-phenylene sulfide), poly(para-phenylene vinylene)s, poly(furan)s, derivatives thereof and mixtures thereof.

9. The medical device of claim 1, said coating comprising poly(pyrrole).

10. The medical device of claim 9 wherein said poly(pyrrole) is doped with perfluorooctane sulfonate.

11. The medical device of claim 1 wherein said coating comprises a porous structure.

12. The medical device of claim 11 wherein said porous structure comprises coarse and fine roughness.

13. The medical device of claim 12 wherein said porous structure comprises pore sizes ranging from about 1 to about 5 microns and from about 10 to about 50 microns.

14. The medical device of claim 1 wherein said medical device is a catheter assembly.

15. The medical device of claim 14 wherein said catheter assembly comprises at least one catheter shaft having a proximal end and a distal end and a distal tip engaged with said distal end of said catheter shaft, said coating disposed on at least a portion of a surface of said expandable member.

16. The medical device of claim 1 wherein said medical device is an expandable member, said coating disposed on at least a portion of a surface of said expandable member.

17. The medical device of claim 1 wherein said medical device is an expandable balloon, said expandable balloon comprising a body, waist and cone portions, said coating disposed on at least the waist portions.

19. The medical device of claim 1 wherein said medical device is a guide wire.

18. The medical device of claim 18 wherein said coating is disposed on at least said waist and cone portions.

20. A method of providing at least a portion of a surface of a catheter assembly with reversibly switchable wettability, the method comprising:

providing a dynamic polymer layer;

providing an electrolyte, said electrolyte in contact with said dynamic polymer layer;

providing a conductive substrate layer electrically connected to a power source, said conductive substrate layer electrically coupled to said dynamic polymer layer;

wherein said electrolyte fluxes in and out of said dynamic polymer layer upon application of electrical potential across the electrolyte between the conductive substrate layer and the dynamic polymer layer, and said dynamic polymer layer exhibits hydrophilic and hydrophobic states.