METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE AND RELATED DISORDERS
First Claim
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1. A method for treating peripheral vascular disease (PVD) in a patient, comprising:
- identifying a patient with PVD; and
providing to the patient by injection an amount of a concentrated population of cells comprising adipose-derived stem cells that is sufficient to restore blood flow to an ischemic region.
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Abstract
Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
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Citations
20 Claims
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1. A method for treating peripheral vascular disease (PVD) in a patient, comprising:
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identifying a patient with PVD; and providing to the patient by injection an amount of a concentrated population of cells comprising adipose-derived stem cells that is sufficient to restore blood flow to an ischemic region.
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2. The method of claim 1, further comprising providing an additive to said concentrated population of cells comprising adipose-derived stem cells.
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3. The method of claim 1, wherein said patient is human.
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4. The method of claim 1, wherein said concentrated population of cells comprising adipose-derived stem cells further comprises adipose-derived progenitor cells.
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5. The method of claim 1, wherein said patient suffers from a defect or disorder of a blood vessel.
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6. The method of claim 1, wherein said patient suffers from Peripheral Artery Disease (PAD).
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7. The method of claim 1, wherein said patient suffers from at least one disease or disorder selected from the group consisting of arteriosclerosis, traumatic injury of vessels and inflammatory arteritides.
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8. The method of claim 1, wherein said patient suffers from a defect or disorder of extracoronary tissue of the patient.
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9. The method of claim 1, wherein said concentrated population of cells comprising adipose-derived stem cells is provided to said patient in multiple doses.
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10. The method of claim 1, further comprising providing one or more angiogenic factors to said patient or to said concentrated population of cells comprising adipose-derived stem cells.
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11. The method of claim 1, further comprising providing one or more immunosuppressive drugs to said patient or to said concentrated population of cells comprising adipose-derived stem cells.
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12. The method of claim 1, wherein said concentrated population of cells comprising adipose-derived stem cells is provided to said patient via at least one of an intravenous, intramuscular or subcutaneous administration route.
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13. The method of claim 1, wherein the concentrated population of cells comprising adipose-derived stem cells is provided to the patient'"'"'s vasculature.
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14. The method of claim 1, wherein said concentrated population of cells comprising adipose-derived stem cells is grown in cell culture prior to being provided to the patient.
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15. The method of claim 14, wherein the cell culture is performed on a scaffold.
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16. The method of claim 15, wherein the scaffold is resorbable in vivo.
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17. The method of claim 1, wherein said concentrated population of adipose-derived stem cells is modified by gene transfer.
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18. The method of claim 17, wherein the modification alters angiogenesis in said patient.
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19. The method of claim 17, wherein the modification improves oxygen supply of pre-existent small blood vessels in said patient.
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20. The method of claim 17, wherein the modification alters the homing properties of the concentrated population of cells comprising adipose-derived stem cells.
Specification